Results 101 to 110 of about 396,290 (347)

Crack Resistance Properties of HPFRC Beam-Column Joints under Cyclic Load

open access: yesAdvances in Materials Science and Engineering, 2019
To investigate the crack resistance properties of high-performance fiber-reinforced concrete (HPFRC) beam-column joints, quasi-static tests of twenty-four beam-column joint specimens were performed.
Dehong Wang, Yanzhong Ju, Hao Shen
doaj   +1 more source

On the mean cluster size of a network of cracks

open access: yesStructural Control and Health Monitoring, 2006
Brittle polycrystalline materials such as rocks, ceramics, and certain metals contain microcracks that can grow and coalesce under sufficiently high stress, resulting in failure and, possibly, fragmentation. Such processes are idealized in this paper by treating the cracks as circular disks whose coalescence forms clusters and can terminate growth ...
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Convergence rates for finite element problems with singularities. Part 1: Antiplane shear [PDF]

open access: yes
The problem of a finite crack in an infinite medium under antiplane shear load is considered. It is shown that the nodal forces at the tip of the crack accurately gives the order of singularity, that n energy release methods can give the strength to ...
Plunkett, R.
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

EFFECT OF PRESTRESSED FORCE AND SIZE OF REINFORCEMENT ON CORROSION CRACK WIDTH IN CONCRETE MEMBER [PDF]

open access: yesJournal of Engineering Science and Technology, 2017
One of the main factors which terminate service life of concrete structure in corrosive environment is corrosion attack. Rust expansion of corroded reinforcement in concrete causes corrosion crack.
AGUS MARYOTO, TAKUMI SHIMOMURA
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Signal Processing for Underclad Crack Sizing

open access: yes, 1985
Underclad cracks in the beltline welds of some pressurized water reactors have been implicated by analysis as a potential safety issue. This issue is known as Pressurized Thermal Shock (PTS) in which a complex sequence of events can, in a very limited number of vessels, cause a small underclad crack (6 mm minimum calculated depth) grow to an ...
Shankar, R.   +3 more
openaire   +3 more sources

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