Results 91 to 100 of about 396,290 (347)
The fatigue crack growth behavior of unreinforced and particulate reinforced Al 2017 alloy, manufactured by powder metallurgy and additional equal-channel angular pressing (ECAP), is investigated.
Lisa Köhler +2 more
doaj +1 more source
Crack Size and Undermatching Effects on Fracture Behavior of a Welded Joint. [PDF]
Sedmak A +5 more
europepmc +1 more source
Ultrasonic Sizing of Cracks in Web Geometries
Evaluation of the critical nature of interior cracks in turbine rotor component web regions in order to assess the remaining service life of the parts requires accurate determination of the crack sizes in order to perform fracture mechanics analysis. This analysis is important both in order to retire critically defective parts and in order to return ...
Gray, Timothy, Thompson, R.Bruce
openaire +3 more sources
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Steady-State Cracks in Viscoelastic Lattice Models II
We present the analytic solution of the Mode III steady-state crack in a square lattice with piecewise linear springs and Kelvin viscosity. We show how the results simplify in the limit of large width. We relate our results to a model where the continuum
C. Bender +16 more
core +2 more sources
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Crack Size Identification for Bearings Using an Adaptive Digital Twin. [PDF]
Piltan F, Kim JM.
europepmc +1 more source
Ratchet limits for a crack in a welded pipe subjected to a cyclic temperature load an a constant mechanical load [PDF]
This paper presents the ratchet limit analysis of a pipe with a symmetric crack in a mismatched weld by using the extended Linear Matching Method (LMM). Two loading conditions are considered: i) a cyclic temperature load and a constant internal pressure;
Chen, Haofeng +3 more
core
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source

