Results 111 to 120 of about 396,290 (347)
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Difracción de rayos X y difracción de neutrones en estudios de fatiga y fractura de materiales [PDF]
, 2019 Conferencia invitada de Joseph F KelleherThe fatigue behaviour of polycrystalline metals is often studied through crack propagation analysis [1,2]. Nevertheless, understanding the mechanical processes that take place right at the crack tip [3,4] would ...
Kelleher, J F
core
, 2018 A microstructure-based model that accounts for the effect of grain size has been developed to study the effect of grain size on the fatigue life of Inconel 718 alloys.
Cruzado, A. +3 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Coarse-grained model of the J-integral of carbon nanotube reinforced polymer composites
, 2016 The J-integral is recognized as a fundamental parameter in fracture mechanics that characterizes the inherent resistance of materials to crack growth.
Arash, Behrouz +2 more
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Correlation between the pivot node concept and fatigue crack closure [PDF]
, 2018 The study of fatigue crack growth has been commonly done by means of bi-dimensional models and assuming a homogeneous behaviour through the thickness. According to the specimen thickness, a state of plane stress or plane strain is presumed.
Camas, Daniel +2 more
core
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Using DOProC method in reliability assessment of steel elements exposed to fatigue
MATEC Web of Conferences, 2017 Fatigue crack damage depends on a number of stress range cycles. This is a time factor in the course of reliability for the entire designed service life.
Krejsa Martin +4 more
doaj +1 more source