Results 71 to 80 of about 396,290 (347)
The effect of white etching layer patches on a larger rail defect
MATEC Web of Conferences, 2017 Manufacturing defects such as porosity that formed in the rail could result in catastrophic failure if it remain in service. In this study, a crack that initiated from a large void was modelled using boundary element model to investigate the effect of ...
Sanusi Shahmir Hayyan, Fletcher David
doaj +1 more source
Mode I crack tip fields: strain gradient plasticity theory versus J2 flow theory
, 2019 The mode I crack tip asymptotic response of a solid characterised by strain gradient plasticity is investigated. It is found that elastic strains dominate plastic strains near the crack tip, and thus the Cauchy stress and the strain state are given ...
Fleck, Norman A. +1 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Practical theories for service life prediction of critical aerospace structural components [PDF]
A new second-order theory was developed for predicting the service lives of aerospace structural components. The predictions based on this new theory were compared with those based on the Ko first-order theory and the classical theory of service life ...
Jackson, Raymond H. +2 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Jixie qiangdu, 2015 In this article,elastic-plastic curved crack tip plasticity area in hardened material under quasi-static loads has been mainly studied,and curved crack tip plasticity area has been calculated as a practical application of a second order perturbation ...
YANG DaPeng, WANG JianXun, ZHAO Yao
doaj
Nihon Kikai Gakkai ronbunshu, 2017 The initiation and growth of internal small fatigue cracks with around ten or several dozen μm in Ti-6Al-4V were nondestructively examined by using synchrotron radiation μCT at the large synchrotron radiation facility SPring-8.
Fumiyoshi YOSHINAKA +5 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
An Improved Method for Hull Structure Fatigue Crack Growth at Random Loading and Its Application
Journal of Marine Science and EngineeringUnder random wave loading, the crack growth rate exhibits jump-like cycle-to-cycle variations, which limit the direct use of efficient integration schemes such as the Euler method.
Ming Zhang +3 more
doaj +1 more source