Results 51 to 60 of about 396,290 (347)
Sensors, 2016 This paper presents a novel framework for probabilistic crack size quantification using fiber Bragg grating (FBG) sensors. The key idea is to use a high-order extended finite element method (XFEM) together with a transfer (T)-matrix method to analyze the
Jingjing He +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2005 This paper presents an experimental study of the fretting crack nucleation threshold, expressed in terms of loading conditions, with a cylinder/plane contact.
Buffiere, Jean-Yves +2 more
core +4 more sources
Computing stress intensity factors for curvilinear cracks [PDF]
, 2015 The use of the interaction integral to compute stress intensity factors around a crack tip requires selecting an auxiliary field and a material variation field.
Buscaglia +34 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Self-stresses and Crack Formation by Particle Swelling in Cohesive Granular Media [PDF]
, 2004 We present a molecular dynamics study of force patterns, tensile strength and crack formation in a cohesive granular model where the particles are subjected to swelling or shrinkage gradients.
D. Maugis +12 more
core +3 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Arbitrary bi-dimensional finite strain crack propagation [PDF]
, 2009 In the past two decades numerous numerical procedures for crack propagation have been developed. Lately, enrichment methods (either local, such as SDA or global, such as XFEM) have been applied with success to simple problems, typically involving some ...
Alfaiate, J. +3 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source