Results 41 to 50 of about 2,962 (211)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

PLASTICITY AREA AT THE THREE DIMENSIONAL CURVED ELASTICITY-PLASTICITY CRACK TIP UNDER QUASI-STATIC LOAD

Jixie qiangdu, 2018
In this article,three dimensional elastic-plastic curved crack tip plasticity area under quasi-static loads has been mainly studied,and three dimensional curved crack tip plasticity area has been calculated as a practical application of a second order ...
YANG DaPeng, PAN HaiYang, ZHANG PinPing, YANG XinHua   +3 more
doaj  

Determination of Fatigue Crack Size in High-Strength Bolting Assemblies Using Hydrogen-Induced Cracking

Engineering Proceedings
For the validation of approaches like fracture mechanics used for the description of crack propagation in high-strength bolting assemblies, it is often necessary to determine the size of an existing crack in the tested assembly.
Fritz Wegener, Ralf Glienke, Daniela Schwerdt, Mathias Lorenz, Justus Mantik, Wilko Flügge   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mechanism of crack branching in the fatigue crack growth path of 2324-T39 Aluminium alloy

Fracture and Structural Integrity, 2015
The crack growth behavior in 2324-T39 aluminium alloy was experimentally investigated. Two types of crack branching were observed. The mechanism of an uncommon crack branching which results from the link up of secondary crack with the main crack was ...
Lu Songsong, Bao Rui, Zhang Ting, Fei Binjun   +3 more
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Fracture behaviors of pre-cracked monolayer molybdenum disulfide: A molecular dynamics study

Beilstein Journal of Nanotechnology, 2016
The fracture strength and crack propagation of monolayer molybdenum disulfide (MoS2) sheets with various pre-existing cracks are investigated using molecular dynamics simulation (MDS).
Qi-lin Xiong, Zhen-huan Li, Xiao-geng Tian   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The effect of white etching layer patches on a larger rail defect

MATEC Web of Conferences, 2017
Manufacturing defects such as porosity that formed in the rail could result in catastrophic failure if it remain in service. In this study, a crack that initiated from a large void was modelled using boundary element model to investigate the effect of ...
Sanusi Shahmir Hayyan, Fletcher David
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source