Results 31 to 40 of about 1,668,091 (242)

About the effect of plastic dissipation in heat at the crack tip on the stress intensity factor under cyclic loading [PDF]

, 2013
Please cite this article as: Ranc, N., Palin-Luc, T., Paris, P.C., Saintier, N., About the effect of plastic dissipation in heat at the crack tip on the stress intensity factor under cyclic loading, International Journal of Fatigue (2013).Because of the ...
PARIS, Paul C., PARIS, Paul Croce, RANC, Nicolas, PALIN-LUC, Thierry, Paris, Paul. C, PARIS, Paul.C., PALIN LUC, Thierry, SAINTIER, Nicolas   +7 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Automatic and time-resolved determination of fracture characteristics from in situ experiments

Materials & Design
The characterization of materials in ever smaller dimensions is crucial for the growing demand for miniaturized devices. Hence, in situ fracture experiments are frequently performed at the micron to sub-micron scale. To evaluate fracture process of these
K. Schmuck, M. Antenreiter, M. Alfreider, D. Kiener   +3 more
doaj   +1 more source

Stress intensity factor of wood from crack-tip displacement fields obtained from digital image processing

Silva Fennica, 2004
Stress intensity factor of radiata pine (Pinus radiata) in Tangential-Longitudinal opening mode was determined from crack-tip displacement fields obtained from digital image correlation in conjunction with orthotropic fracture theory. For lower loads,
Samarasinghe, Sandhya, Kulasiri, Don
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Interaction of a finite crack with shear waves in an infinite magnetoelastic medium

Applied and Computational Mechanics, 2021
The aim of this paper is to investigate the interaction of a finite crack with shear waves in an infinite magnetoelastic medium. Fourier integral transformation is applied to convert the boundary value problem for a homogeneous,isotropic elastic material
Panja S.K., Mandal S.C.
doaj   +1 more source

Some experimental observations of crack-tip mechanics with displacement data [PDF]

, 2015
Estudio de la mecánica en el vértice de la grieta mediante datos de desplazamiento.In the past two decades, crack-tip mechanics has been increasingly studied with full-field techniques.
Moreno-Morales, María Belén, Moreno, B, Zanganeh, M, P. Lopez-Crespo, Mokhtari, M, M. Zanganeh, B. Moreno, Lopez-Crespo, P., Moreno, B., López-Crespo, Pablo, Mokhtari, M., M. Mokhtari, Zanganeh, M.   +12 more
core   +2 more sources