Results 121 to 130 of about 636,508 (285)
BuildingsExpansive clays present serious issues in a variety of engineering applications, including roadways, light buildings, and infrastructure, because of their notable volume changes with varying moisture content.
Abdullah A. Shaker +3 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Numerical prediction of crack formation in historic masonry buildings
Magazine of Civil EngineeringThis article investigated mechanical behavior of the masonry of historic buildings. It was assumed that reliable cracking processes can be obtained by modeling masonry as a continuous medium and using the Jointed Masonry Model (JMM).
Iovlev Gregorii +2 more
doaj +1 more source
Line Spring Model and Its Applications to Part-Through Crack Problems in Plates and Shells [PDF]
The line spring model is described and extended to cover the problem of interaction of multiple internal and surface cracks in plates and shells. The shape functions for various related crack geometries obtained from the plane strain solution and the ...
Aksel, B., Erdogan, F.
core +1 more source
Effect of Notches on the Axial Fatigue Properties of Structural Steels [PDF]
, 1963 The effect of the stress concentration on the zero-to-tension axial fatigue strength of notched members of four structural steels has been studied. For each of the four steels a critical notch severity was found at which a transition in behavior takes
Munse, W.H. +2 more
core
ON CRACK CLOSURE IN FATIGUE CRACK GROWTH
, 1978 A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Meitan kexue jishuThe clean and efficient development of tar-rich coal is helpful in ensuring China's energy security. The tar-rich coal from Ningtiaota Mine was selected and heated under N2 and hypoxia atmosphere.
Shuangming WANG +6 more
doaj +1 more source
Crack growth criteria and crack tip models
, 1988 Summary: The current status of crack tip characterizations is reviewed. Several unresolved areas for further research are identified. Singular fields for stationary and moving crack tips in different nonlinear materials are reviewed and special emphasis is put on the extension of the region where these fields dominate.
Nilsson, Fred, Ståhle, P.
openaire +2 more sources