Results 71 to 80 of about 390,574 (294)

Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.

, 2016
Craniofacial abnormalities are among the most common features of human genetic syndromes and disorders. The etiology of these conditions is often complex, influenced by both genetic context and the environment.
Bergstrom, David E, Fairfield, Heather, Cox, Timothy C, Reinholdt, Laura G, Donahue, Leah Rae, Palmer, Kristina, Curtain, Michelle, Karst, Son Yong, Bronson, Roderick T, Hassan, Mohamed G, Borgeia, Suhaib, Murray, Stephen A, Dionne, Louise A, Coombs, Harold   +13 more
core   +1 more source

FREQUENCY OF SINO-NASAL ABNORMALITIES AND ASSOCIATED SOCIODEMOGRAPHIC FACTORS AMONG THE PATIENTS PRESENTING WITH CRANIOFACIAL PAINS AT ENT DEPARTMENT

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine the frequency of sino-nasal abnormalities and associated socio-demographic factors among the patients presenting with craniofacial painat ENT department of a tertiary care hospital of Pakistan Study Design: Cross-sectional ...
Humza Mumtaz, Usama Bin Zubair
doaj   +4 more sources

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

A distant global control region is essential for normal expression of anterior HOXA genes during mouse and human craniofacial development

Nature Communications
Craniofacial abnormalities account for approximately one third of birth defects. The regulatory programs that build the face require precisely controlled spatiotemporal gene expression, achieved through tissue-specific enhancers.
Andrea Wilderman, Eva D’haene, Machteld Baetens, Tara N. Yankee, Emma Wentworth Winchester, Nicole Glidden, Ellen Roets, Jo Van Dorpe, Sandra Janssens, Danny E. Miller, Miranda Galey, Kari M. Brown, Rolf W. Stottmann, Sarah Vergult, K. Nicole Weaver, Samantha A. Brugmann, Timothy C. Cox, Justin Cotney   +17 more
doaj   +1 more source

Single‐Cell RNA Sequencing of Peripheral Blood Defines Two Immunologic Subtypes of Sjögren's Disease Distinguished by Anti‐SSA Antibodies and Aberrant B Cell Populations

Arthritis &Rheumatology, EarlyView.
Objective Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes.
Geoffrey Urbanski, Kimberly E. Taylor, Emily Flynn, Armita Norouzi, Catherine Chu, Brittany Davidson, Arnab Ghosh, Joanne Nititham, Ravi K. Patel, Annie W. Poon, Gabriela K. Fragiadakis, Alexis J. Combes, Walter L. Eckalbar, Lindsey A. Criswell, Chun Jimmie Ye, Caroline H. Shiboski   +15 more
wiley   +1 more source

Genetics: GTF2IRD1 in craniofacial development of humans mice

, 2005
Craniofacial abnormalities account for about one-third of all human congenital defects, but our understanding of the genetic mechanisms governing craniofacial development is incomplete.
Stewart, Helen, Read, Andrew P., Marian E Durkin (16067171), Durkin, Marian E., Tassabehji, May, Mark Maconochie (16061054), Hutton, Timothy, Donnai, Dian, May Tassabehji (123811), Thorgeireson, Snorri S., Nicholas C Popescu (16067174), Pamela Thompson (449563), Thompson, Pamela, Metcalfe, Kay, Annette Karmiloff-Smith (802535), Timothy Hutton (16067177), Andrew P Read (16067183), Rucka, Agnes, Snorri S Thorgeirsson (16067168), Kay Metcalfe (9045488), Agnes Rucka (16067180), Hammond, Peter, Dian Donnai (8432907), Helen Stewart (7314533), Maconochie, Mark, Karmiloff-Smith, Annette, Popescu, Nicholas C., Peter Hammond (140939)   +27 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Optimized micro‐sized cell sphere‐matrix niche co‐aggregates promote efficient oral and craniomaxillofacial bone regeneration

BMEMat, EarlyView.
The construct of cell‐niche co‐aggregates (GelMA‐SHED sphere‐DDMPs) promotes cranial and periodontal bone regeneration and ensures angiogenic‐osteogenic coupling by downregulating miR‐34c‐5p to enhance the expression of NOTCH1 and its intracellular domain (NICD).
Xiao‐Hui Zhang, Shi‐Han Mu, Yi‐Han Xiao, Lu‐Fan Yang, Peng‐Fei Wang, Teng‐Fei Hu, Jun‐Xi He, Jiong‐Zhen Piao, Sha Zhang, Jin‐Yu Liu, Yi‐De He, Ying‐Ying Wu, Si‐Qi Ying, Xin‐Yue Cai, Chen‐Han Li, Zi‐Qi Zhang, Xiao Lei, Ji Chen, Jian‐Fei Liang, Yan Jin, Bing‐Dong Sui, Chao Ma, Chen‐Xi Zheng, Fang Jin   +23 more
wiley   +1 more source

Craniofacial bone abnormalities and malocclusion in individuals with sickle cell anemia: a critical review of the literature

, 2012
This study aims to critically review the literature in respect to craniofacial bone abnormalities and malocclusion in sickle cell anemia individuals.
Halinna Larissa Cruz Correia de Carvalho, Cyrene Piazera Silva Costa, Erika Bárbara Abreu Fonseca Thomaz, Soraia de Fátima Carvalho Sousa   +3 more
core   +1 more source