Results 41 to 50 of about 305,765 (260)
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
Correlation and assessment of structural airplane crash data with flight parameters at impact [PDF]
Crash deceleration pulse data from a crash dynamics program on general aviation airplanes and from transport crash data were analyzed. Structural airplane crash data and flight parameters at impact were correlated.
Carden, H. D.
core +1 more source
Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
AZIPOD Propeller Blade Cavitation Observations During Ship Maneuvering [PDF]
, 2001 This paper presents results of observations of full-scale propeller blade cavitation patterns carried out on the Elation passenger cruiser, the very first ship equipped with AZIPOD electric thrusters. It offers descriptions of test conditions, cavitation
Kaprantsev, Sergey, Pustoshny, Alexander
core
A prospective, population-based study of the role of visual impairment in motor vehicle crashes among older drivers: the SEE study. [PDF]
, 2007 PURPOSE: To determine the role of vision and visual attention factors in automobile crash involvement. METHODS: Drivers aged 65 to 84 years were identified during the baseline interview (1993-1995) of the Salisbury Eye Evaluation (SEE) Study.
Bandeen-Roche, Karen +5 more
core +1 more source
Advanced Science, EarlyView.SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang +8 more
wiley +1 more source
Does the bond-stock earning yield differential model predict equity market corrections better than high P/E models? [PDF]
, 2014 In this paper, we extend the literature on crash prediction models in three main respects. First, we relate explicitly crash prediction measures and asset pricing models.
Lleo, Sebastien, Ziemba, William T.
core
Advanced Science, EarlyView.Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun +11 more
wiley +1 more source
Impact dynamics research facility for full-scale aircraft crash testing [PDF]
An impact dynamics research facility (IDRF) was developed to crash test full-scale general aviation aircraft under free-flight test conditions. The aircraft are crashed into the impact surface as free bodies; a pendulum swing method is used to obtain ...
Alfaro-Bou, E., Vaughan, V. L. J.
core +1 more source
The Biofuels Blueprint: Understanding the U.S. Renewable Fuel Standard
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT We provide a comprehensive review of the U.S. Renewable Fuel Standard (RFS), synthesizing nearly two decades of program evolution, market outcomes, and economic analysis. The RFS mandates minimum volumes of renewable fuel blending through a nested structure based on life‐cycle greenhouse gas reductions, enforced via tradeable Renewable ...
Maria Gerveni +3 more
wiley +1 more source