Results 21 to 30 of about 42,801 (258)

Differing patterns of stress and craving across the day in moderate-heavy alcohol consumers during their typical drinking routine and an imposed period of alcohol abstinence. [PDF]

PLoS ONE, 2018
BACKGROUND:Stress is a known factor related to alcohol use. However, how the relationship between alcohol craving and stress varies across the day is not fully understood.
Rhiannon E Mayhugh, W Jack Rejeski, Meredith R Petrie, Paul J Laurienti, Lise Gauvin   +4 more
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Rocavorexant, a novel, selective orexin‐1 receptor antagonist: Safety, tolerability and pharmacokinetics in healthy adults and individuals with opioid use disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Rocavorexant (INDV‐2000), a selective orexin‐1 receptor antagonist, reduces drug self‐administration and anxiety in nonclinical studies. This Phase 1 programme evaluated the safety, pharmacokinetics and pharmacodynamics of rocavorexant in healthy volunteers and treatment‐seeking individuals with opioid use disorder (OUD).
Martin Kankam, Rana Al‐Awam, Rajinder Shiwach, Andrew S. Huhn, Malcolm A. Young, Robert L. Dobbins   +5 more
wiley   +1 more source

Glucagon‐like peptide‐1 receptor agonists in schizophrenia spectrum disorders: A systematic review and meta‐analysis of efficacy, safety and mental health outcomes

British Journal of Clinical Pharmacology, EarlyView.
Aims The purpose of this study is to evaluate efficacy, safety and mental‐health outcomes of glucagon‐like peptide‐1 (GLP‐1) receptor agonists in adults with overweight or obesity and antipsychotic‐treated schizophrenia‐spectrum disorders. Methods PubMed/MEDLINE, Embase, PsycINFO, CENTRAL, Virtual Health Library (VHL) (Biblioteca Virtual em Saúde, BVS),
Débora Regina de Aguiar, Samuel Izaias dos Santos Pereira, Pedro Batista Castro, Carlos Ricardo Oliveira Carneiro, Julia Costa de Araujo, Rebeca Ferreira de Souza, Otavio André Farias Sousa da Silva, Matheus Hissa Lourenço Ferreira, Bruna Loureiro Fontana Bolsoni, Nelson Carvas Junior, Mario Rodrigues Louzã   +10 more
wiley   +1 more source

Exploring the relationship between cue-induced craving and withdrawal craving in MUD individuals based on a virtual-reality cue exposure paradigm

BMC Psychiatry
Background This study developed a virtual reality (VR) drug cue exposure paradigm for individuals with methamphetamine use disorder (MUD) to investigate the characteristics of withdrawal craving and cue-induced craving and their relationship.
Qiuping Huang, Xinxin Chen, Ying Tang, Xuhao Wang, Wenwu Wang, Li Chao, Yiqi Nie, Shihua Peng, Lin Zhao, Hongxian Shen, Zhenjiang Liao   +10 more
doaj   +1 more source

Incubation of cocaine craving coincides with changes in dopamine terminal neurotransmission

Addiction Neuroscience, 2022
Relapse to drug use is one of the major challenges in treating substance use disorders. Exposure to drug-related cues and contexts triggers drug craving, which drives cocaine seeking, and increases the probability of relapse.
I. Pamela Alonso, Bethan M. O'Connor, Kathleen G. Bryant, Rushi K. Mandalaywala, Rodrigo A. España   +4 more
doaj   +1 more source

Peer Versus Top Management Communication and Energy‐Saving Behavioural Intentions in the Workplace: The Moderating Role of Personalised Framing

Business Strategy and the Environment, EarlyView.
ABSTRACT Employee engagement is pivotal for corporate sustainability, yet the role of information design in internal employee communication remains under‐specified. Drawing on Construal Level Theory, this study examines whether the effect of information sender (peer vs top management communication) on employees' energy‐saving behavioural intentions ...
Franziska Brack
wiley   +1 more source

Molecular mechanisms involved in alcohol craving, IRF3, and endoplasmic reticulum stress: a multi-omics study

Translational Psychiatry
Alcohol use disorder (AUD) is the most prevalent substance use disorder worldwide. Acamprosate and naltrexone are anti-craving drugs used in AUD pharmacotherapy. However, molecular mechanisms underlying their anti-craving effect remain unclear.
Ming-Fen Ho, Cheng Zhang, Irene Moon, Mustafa Tuncturk, Brandon J. Coombes, Joanna Biernacka, Michelle Skime, Tyler S. Oesterle, Victor M. Karpyak, Hu Li, Richard Weinshilboum   +10 more
doaj   +1 more source

Investigating the Customer Journey in Second‐Hand Fashion Platforms: Implications for Luxury Brand Management

Journal of Consumer Behaviour, Volume 24, Issue 2, Page 655-672, March 2025.
ABSTRACT Consumers' increasing environmental concerns are prompting a shift in fashion consumption, fueling the remarkable growth of the second‐hand market. Over the last decade, this trend has spurred the emergence of a plethora of online platforms dedicated to the resale of pre‐loved fashion items.
Gabriele Murtas, Giuseppe Pedeliento
wiley   +1 more source

An ideographic study into physiology, alcohol craving and lapses during one hundred days of daily life monitoring

Addictive Behaviors Reports, 2022
Introduction: Alcohol craving is a highly challenging obstacle to achieve long-term abstinence. Making alcohol use disorder patients timely aware of high-risk craving situations may protect them against relapse by prompting them to mobilize their coping ...
Hendrika G. van Lier, Matthijs L. Noordzij, Marcel E. Pieterse, Marloes G. Postel, Miriam M.R. Vollenbroek-Hutten, Hein A. de Haan, Jan Maarten C. Schraagen   +6 more
doaj   +1 more source