Results 31 to 40 of about 52,282 (302)

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

Exploring the relationship between cue-induced craving and withdrawal craving in MUD individuals based on a virtual-reality cue exposure paradigm

BMC Psychiatry
Background This study developed a virtual reality (VR) drug cue exposure paradigm for individuals with methamphetamine use disorder (MUD) to investigate the characteristics of withdrawal craving and cue-induced craving and their relationship.
Qiuping Huang, Xinxin Chen, Ying Tang, Xuhao Wang, Wenwu Wang, Li Chao, Yiqi Nie, Shihua Peng, Lin Zhao, Hongxian Shen, Zhenjiang Liao   +10 more
doaj   +1 more source

The Impact of Co-occurring Post-traumatic Stress Disorder and Substance Use Disorders on Craving: A Systematic Review of the Literature

Frontiers in Psychiatry, 2021
The frequent co-occurrence of post-traumatic stress disorder (PTSD) and substance use disorders (SUDs) leads to manifestations of both conditions that are more severe and more resistance to treatment than single disorders.
Fabien Renaud, Louise Jakubiec, Louise Jakubiec, Joel Swendsen, Joel Swendsen, Melina Fatseas, Melina Fatseas   +6 more
doaj   +1 more source

Stress reactivity in heroin dependence [PDF]

, 2015
Background: Heroin dependence is a chronic relapsing disorder characterized by a compulsion to seek and use heroin despite the negative consequences. In addition to the diagnostic criteria, heroin dependence is associated with an altered function of the ...
Gerber, Hana
core   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Molecular mechanisms involved in alcohol craving, IRF3, and endoplasmic reticulum stress: a multi-omics study

Translational Psychiatry
Alcohol use disorder (AUD) is the most prevalent substance use disorder worldwide. Acamprosate and naltrexone are anti-craving drugs used in AUD pharmacotherapy. However, molecular mechanisms underlying their anti-craving effect remain unclear.
Ming-Fen Ho, Cheng Zhang, Irene Moon, Mustafa Tuncturk, Brandon J. Coombes, Joanna Biernacka, Michelle Skime, Tyler S. Oesterle, Victor M. Karpyak, Hu Li, Richard Weinshilboum   +10 more
doaj   +1 more source

Food cue-induced craving in individuals with bulimia nervosa and binge-eating disorder. [PDF]

PLoS ONE, 2018
Individuals with bulimia nervosa (BN) or binge-eating disorder (BED) experience more frequent and intense food cravings than individuals without binge eating.
Adrian Meule, Carolyn Küppers, Louisa Harms, Hans-Christoph Friederich, Ulrike Schmidt, Jens Blechert, Timo Brockmeyer   +6 more
doaj   +1 more source

Food‐Related Attentional Biases in Restrained Eaters: A Meta‐Analysis

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Dietary restraint may contribute to the development and maintenance of eating disorders (EDs), with food‐related attentional biases (ABs) as a key underlying mechanism. We examined associations between dietary restraint and ABs and explored how several methodological factors (i.e., AB mechanism, mode of AB investigation, response ...
Rio Madan, Cristina Martinelli
wiley   +1 more source

From game engagement to craving responses – The role of gratification and compensation experiences during video-gaming in casual and at-risk gamers

Addictive Behaviors Reports, 2023
Introduction: Although playing videogames is a common leisure activity some individuals develop problematic gaming behaviors or even symptoms of a gaming disorder.
S. Antons, M. Liebherr, M. Brand, A. Brandtner   +3 more
doaj   +1 more source

Experiencing Extreme Hunger in Anorexia Nervosa Recovery: A Qualitative Analysis of Reddit Narratives

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Recovery from anorexia nervosa involves psychological and social adjustments that extend beyond weight restoration. Online forums increasingly serve as spaces where recovery experiences are openly shared, including accounts of “extreme hunger” during refeeding—a phenomenon that has not been reported in the clinical literature.
Léonie Langanay, Charlotte Meric, Margot Trimbur, Joël Charbit, Maxime Bubrovszky, Marion Hendrickx, Antoine Lamer   +6 more
wiley   +1 more source