Results 41 to 50 of about 943,536 (329)
Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency [PDF]
, 2016 Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver. We previously generated a tamoxifen-inducible Arg1 deficient mouse model (Arg1-Cre) that disrupts Arg1 expression throughout the whole body and leads
Al-Dirbashi, Osama Y. +5 more
core +1 more source
Class community as a positive: Development and therapeutic communities [PDF]
Univerzitetska Misao, 2018 Positive-development innovations, as new strategies of positive and healthy development, should be used in all segments of learning and development in all forms of teaching, sections, and extracurricular activities to encourage positive, healthy and ...
Hajder Muradif
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Infectio, 2020 Objectives: The Dominican Republic lacks reliable information on antimicrobial resistance (AMR), which would allow physicians to prescribe the best treatment for common infectious diseases. This study aimed to define the antimicrobial resistance profiles
David de Luna
doaj +1 more source
A consistent interpretation of recent CR nuclei and electron spectra [PDF]
, 2011 We try to interpret the recently updated measurement of the cosmic ray electron (CRE) spectrum observed by Fermi-LAT, together with PAMELA data on positron fraction, in a single-component scenario adopting different propagation setups; we find that the ...
Di Bernardo, Giuseppe +5 more
core +2 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Educação Inclusiva da utopia a uma política educacional
Contexto & Educação, 2013 Este texto propõe uma reflexão sobre a Educação Inclusiva, que se apresenta como um novo paradigma educacional, a partir dos princípios estabelecidos pela Constituição Federal de 1988 e pela Lei de Diretrizes e Bases da Educação Nacional, Lei nº 9394/96.
Lenir Santos Schettert
doaj +1 more source
Self Organizing strategies for enhanced ICIC (eICIC) [PDF]
, 2014 Small cells have been identified as an effective solution for coping with the important traffic increase that is expected in the coming years. But this solution is accompanied by additional interference that needs to be mitigated. The enhanced Inter Cell
Altman, Eitan +2 more
core +4 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Endothelial-Specific Cre Mouse Models [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018 The field of vascular biology has gained enormous insight from the use of Cre and inducible Cre mouse models to temporally and spatially manipulate gene expression within the endothelium. Models are available to constitutively or inducibly modulate gene expression in all or a specified subset of endothelial cells.
Payne, S, De Val, S, Neal, A
openaire +1 more source