Results 61 to 70 of about 232,081 (310)
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
CRE-dependent PRV-GFP activation in Kiss1 neurons.
, 2019 Stereotaxic delivery of the PRVINTRO virus into the arcuate (ARC) region of mice was associated with GFP expression only in Kiss1-CRE mice. PRVINTRO driven GFP expression (arrowed) at 24 h after delivery was restricted to Kiss1 neurons (A) but at 48 h ...
Clemence Blouet (6519428) +4 more
core +1 more source
Journal of Pure and Applied MicrobiologyThe presence of ESBLs and CRE in E. coli and Klebsiella pneumoniae poses a significant challenge in healthcare and community settings. These enzymes can confer resistance to multiple antibiotics, limiting treatment options for infections caused by these ...
Samreen Soomro +8 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui +14 more
wiley +1 more source
, 2018 Fasciculation defects in the Emx1-Cre:CB1-Rf/f cross (A-C) illustrated with Fluoromyelin red (A, WT; B, Emx1-KO) and Sudan Black (C, Emx1-KO). CB1-R immunoreactivity was similar in striosomes in Emx1-Cre wildtype (D) and littermate Emx1-Cre;CB1-Rf/f ...
Jill R. Crittenden (237710) +7 more
core +1 more source
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Validation of a ROSA26-CRE-luc knock-in mouse.
, 2016 (A) Schematic of ROSA26-CRE-luc knock-in construct. (B) Bioluminescence imaging of male ROSA26-CRE-luc knock-in mice, ad libitum fed (ZT0) and after a 6-h fast (ZT6) (5 sec exposure).
Kavitha Rajendran (290685) +3 more
core +1 more source
Pharmaceutics, 2020 It is now widely appreciated that gastrointestinal function is central to the regulation of metabolic homeostasis. Following meal ingestion, the delivery of nutrients from the stomach into the small intestine (i.e., gastric emptying) is tightly ...
Cong Xie +3 more
doaj +1 more source
Climate Change Threatens Micronutrient Density of European Winter Wheat
Advanced Science, EarlyView.Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao +17 more
wiley +1 more source
Journal of Pure and Applied MicrobiologyUrinary tract infections (UTIs) are most common infections encountered in both community and hospital settings and are frequently treated with antibiotics.
Susmitha Simgamsetty +3 more
doaj +1 more source