Results 71 to 80 of about 232,081 (310)

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Assessing Risk Factors and Clinical Implications of Carbapenem-resistant Enterobacterales Infections in a Tertiary Care Setting

Journal of Pure and Applied Microbiology
Carbapenem-resistance in Gram-negative bacteria poses a global threat, necessitating vigilant surveillance for informed policy decisions. Our study investigated clinically significant, carbapenem-resistant Enterobacterales infections.
Sevitha Bhat, Joanne Mathew, Nigitha Prasad, K. Archana Bhat, Shalini Shenoy Mulki   +4 more
doaj   +1 more source

Jaffe's kinetic method comparison between isotope dilution mass spectrometry standardized versus nonstandardized method

Indian Journal of Health Sciences and Biomedical Research KLEU, 2020
INTRODUCTION: Serum creatinine is estimated by several methods in different laboratories, having varying degrees of bias and imprecision, leading to different values across the laboratories with the same sample.
Girish Konasagara Shanthaveeranna, Anitha Devanath   +1 more
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

AAV2-Cre-mediated reporter gene expression in the brain.

, 2016
(A) Co-localization of Cre-immunoreactive nuclei (green) and tdTomato immunoreactivity (red) in the same cells [merged image and the 3D reconstruction image (A′)]. (B) Quantitative analysis for the in vivo recombination efficiency. 525(+)/590(-) or 525(+)
Hiroyuki Igarashi (766286), Kyo Koizumi (2795344), Ryosuke Kaneko (2795341), Yuchio Yanagawa (50724), Toru Ishizuka (180182), Shin-ichi Muramatsu (115935), Ryo Egawa (241153), Hiromu Yawo (180186), Hiroshi Onimaru (766288), Keiko Ikeda (2795338)   +9 more
core   +1 more source

Embracing the Emic of Minahasa celebration culture and Christian Religious Education

HTS Teologiese Studies/Theological Studies
Christian Religious Education (CRE) studies are often known to neglect the incorporation of local culture, as regulations primarily mandate the inclusion of Christian dogmatics and social issues.
Demsy Jura, Pantjar Simatupang, Christar A. Rumbay   +2 more
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

LyzM-cre-mediated β-catenin knockout does not affect lupus pathogenesis.

, 2016
B6 mice were bred to produce mice expressing the lupus-susceptibility locus Sle1, the lupus-accelerating locus Yaa (males only), and β-catenin-floxed loci in the presence or absence of the LyzM-cre locus. Mice expressing all of these loci are genetically
Jacob J. Orme (3070707), Chandra Mohan (157054), Yong Du (86188), Kamala Vanarsa (3070704), Tianfu Wu (156995), Anne B. Satterthwaite (426068)   +5 more
core   +1 more source

Eight-Year Surveillance of Uropathogenic Escherichia coli in Southwest China

Infection and Drug Resistance, 2020
Jide Sun,1 Li Du,2 Li Yan,1 Wei Dai,1 Zhu Wang,1 Xiuyu Xu1 1Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2College of Basic Science, Chongqing Medical ...
Sun J, Du L, Yan L, Dai W, Wang Z, Xu X
doaj