Results 91 to 100 of about 232,081 (310)

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Faecal Carriage of Carbapenem-resistant Enterobacterales in a Tertiary Care Teaching Hospital in Mumbai

Journal of Pure and Applied Microbiology
CRE colonization can act as a potential source for subsequent infection with high mortality rate. This study was to determine prevalence of faecal carriage of CRE among hospitalized patients and the associated risk factors for acquisition.
Bhagyashree Kadam, Priyanka Sheshnath Prasad, Gita Nataraj   +2 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

sj-pdf-1-cre-10.1177_02692155211034149 – Supplemental material for Evaluation of the predictive validity of the Hessisch Oldendorf Risk of Falling Scale (HOSS)

, 2021
Supplemental material, sj-pdf-1-cre-10.1177_02692155211034149 for Evaluation of the predictive validity of the Hessisch Oldendorf Risk of Falling Scale (HOSS) by Simone B Schmidt, Melanie Boltzmann and Jens D Rollnik in Clinical ...
Melanie Boltzmann (9028370), Simone B Schmidt (11251594), Jens D Rollnik (11251597)   +2 more
core   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

sj-docx-3-cre-10.1177_02692155221137640 - Supplemental material for Preventive interventions for lateral ankle sprains: A systematic review and meta-analysis

, 2023
Supplemental material, sj-docx-3-cre-10.1177_02692155221137640 for Preventive interventions for lateral ankle sprains: A systematic review and meta-analysis by Fanjia Wang, Yonghao Guan, Zoe Bamber, Xianxin Cao, Qi Qi, Wenxin Niu and Bin Chen in Clinical
Zoe Bamber (9622394), Fanjia Wang (14420996), Qi Qi (556563), Yonghao Guan (14420999), Wenxin Niu (547592), Bin Chen (63682), Xianxin Cao (14421002)   +6 more
core   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

sj-docx-3-cre-10.1177_02692155231158475 - Supplemental material for Development and validation of the MAnchester Needs Tool for Injured Children (MANTIC)

, 2023
Supplemental material, sj-docx-3-cre-10.1177_02692155231158475 for Development and validation of the MAnchester Needs Tool for Injured Children (MANTIC) by Samantha Jones, Sarah Tyson and Janelle Yorke in Clinical ...
Samantha Jones (119038), Sarah Tyson (3494612), Janelle Yorke (5873297)   +2 more
core   +1 more source

Adenine overload induces ferroptosis in human primary proximal tubular epithelial cells

Cell Death and Disease, 2022
Muhammad Ali Khan, Purba Nag, Anca Grivei, Kurt T. K. Giuliani, Xiangju Wang, Vishal Diwan, Wendy Hoy, Helen Healy, Glenda Gobe, Andrew J. Kassianos   +9 more
doaj   +1 more source