Results 101 to 110 of about 997,878 (328)

Visual Tuning Properties of Genetically Identified Layer 2/3 Neuronal Types in the Primary Visual Cortex of Cre-Transgenic Mice

Frontiers in Systems Neuroscience, 2011
The putative excitatory and inhibitory cell classes within the mouse primary visual cortex V1 have different functional properties as studied using recording microelectrode.
Hatim A Zariwala, Hatim A Zariwala, Linda Madisen, Kurt F Ahrens, Amy Bernard, Edward S Lein, Allan R Jones, Hongkui Zeng   +7 more
doaj   +1 more source

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]

, 2017
We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo, Chiorini, John A., Crispino, Giulia, Di Pasquale, Giovanni, Galindo Ramirez, Fabian, Mammano, Fabio, Praetorius, Mark, Zorzi, Veronica   +7 more
core   +1 more source

Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse

Scientific Reports, 2017
Rhythm generating neurons are thought to be ipsilaterally-projecting excitatory neurons in the thoracolumbar mammalian spinal cord. Recently, a subset of Shox2 interneurons (Shox2 non-V2a INs) was found to fulfill these criteria and make up a fraction of
Vanessa Caldeira, Kimberly J. Dougherty, Lotta Borgius, O. Kiehn   +3 more
semanticscholar   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]

, 2018
Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3.
Herz, Joachim, Holtzman, David M, Ma, Qingyi, Owens, Nelly Chuqui, Sagare, Abhay P, Verghese, Philip B, Wang, Min, Wu, Yingxi, Zhao, Zhen, Zlokovic, Berislav V   +9 more
core   +3 more sources

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia [PDF]

, 2016
The transgenic and knockout (KO) animals involving Fgf23 have been highly informative in defining novel aspects of mineral metabolism, but are limited by shortened lifespan, inability of spatial/temporal FGF23 control, and infertility of the global KO ...
Allen, Matthew R., Bellido, Teresita, Cass, Taryn A., Clinkenbeard, Erica L., Hum, Julia M., Ni, Pu, White, Kenneth E.   +6 more
core   +1 more source

Annotated CREs

, 2023
Data frame containing diverse annotations of human cis-regulatory elements CREs. Annotations include epigenetic signals of histone modification marks, conservation, and methylation scores. Annotations also include the number of active cell types that each CRE is active on and other annotations describing the location of each CRE in the genome.
openaire   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Income, human capital and pollution: a multi-emission approach to the EKC hypothesis

Cogent Economics & Finance
This article reexamines the relationship between per capita income and environmental quality, with a particular emphasis on the role of education. Using a panel of 154 countries classified by income level (high, lower middle, upper middle and low), and ...
Djomélo Rock Voda, Jude Eggoh, Louis-Joel Basneouinde Diendere   +2 more
doaj   +1 more source