Results 111 to 120 of about 997,878 (328)
Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]
, 2017 Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran +15 more
core +2 more sources
Advanced Science, EarlyView.Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater +13 more
wiley +1 more source
Ethnic minority business: policy and practice review [PDF]
, 2009 Part of a series produced to support a ESRC/CRE/DTI/emda workshop on ethnic minority entrepreneurship. This paper identifies the key problems in addressing racism and ethnicity in extant cross-governmental policy and practice relating to ...
Law, I
core
Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, EarlyView.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
Journal of Pure and Applied MicrobiologyCRE colonization can act as a potential source for subsequent infection with high mortality rate. This study was to determine prevalence of faecal carriage of CRE among hospitalized patients and the associated risk factors for acquisition.
Bhagyashree Kadam +2 more
doaj +1 more source
Transcriptional control by the CRE-binding protein, CRE-BP1.
Seibutsu Butsuri, 1993 Two of the major classes of regulatory elements which contribute to transcriptional regulation by extracellular signals are the TRE and CRE sequence motifs. We have isolated the CRE-binding protein, CRE-BP1, which has a zinc finger structure as a transactivation domain located at the amino terminus and a leucine zipper motif found at the carboxy ...
Toshio MAEKAWA, Shunsuke ISHI
openaire +1 more source
Advanced Science, EarlyView.We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang +10 more
wiley +1 more source
Infection and Drug Resistance, 2019 This observational study aimed to identify the independent risk factors for both the acquisition and mortality of carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CP-CRE) bacteremia and further assess the in vitro antimicrobial activities of ceftazidime-avibactam (CAZ/AVI) and aztreonam-avibactam (ATM/AVI) against recent CRE bacteremic ...
Hua Zou +5 more
openaire +3 more sources
ELABELA Targets Mitochondria to Modulate Heart Development
Advanced Science, EarlyView.The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang +22 more
wiley +1 more source