Results 121 to 130 of about 997,878 (328)
Adenine overload induces ferroptosis in human primary proximal tubular epithelial cells
Cell Death and Disease, 2022 Muhammad Ali Khan +9 more
doaj +1 more source
A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis
Advanced Science, EarlyView.This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou +14 more
wiley +1 more source
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
Molecular Brain, 2012 The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world.
E. Kandel
semanticscholar +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
Advanced Science, EarlyView.With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao +16 more
wiley +1 more source
Infection and Drug ResistancePingjuan Liu,1,* Mengling Qin,2,* Chenfeng Zhao,1,* Siting Yi,3 Mengmin Ye,3 Kang Liao,1 Jiankai Deng,1 Yili Chen1 1Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510080 ...
Liu P +7 more
doaj
Advanced Science, EarlyView.Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen +16 more
wiley +1 more source
Infection and Drug Resistance, 2022 Qin Hu,1– 4,* Jinglan Chen,1,2,5,* Shusen Sun,1,6 Sheng Deng1,2,5 1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Institute for Rational and Safe Medication Practices, National Clinical ...
Hu Q, Chen J, Sun S, Deng S
doaj
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source