Results 81 to 90 of about 232,081 (310)

Visual Tuning Properties of Genetically Identified Layer 2/3 Neuronal Types in the Primary Visual Cortex of Cre-Transgenic Mice

Frontiers in Systems Neuroscience, 2011
The putative excitatory and inhibitory cell classes within the mouse primary visual cortex V1 have different functional properties as studied using recording microelectrode.
Hatim A Zariwala, Hatim A Zariwala, Linda Madisen, Kurt F Ahrens, Amy Bernard, Edward S Lein, Allan R Jones, Hongkui Zeng   +7 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications [PDF]

, 2019
Most biomedical research aimed at understanding gene function uses the Cre-Lox system, which consists of the Cre recombinase-dependent deletion of genes containing LoxP sites.
Rocha, Susana, Francesca Lunella, Federica, Benedito, Rui, Casquero-Garcia, Veronica, Ferreira Rocha, Susana, Del Olmo-Cabrera, Sergio, Fernandez-Chacon, Macarena, Lunella, Federica Francesca, Luo, Wen   +8 more
core   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Presentación

, 2005
Cuadernos de Rusística Española (CRE) es una publicación del Grupo de Investigación «Investigaciones de Filología Eslava» (HUM- 417) de la Junta de Andalucía.
revista, cre
core   +1 more source

Cre-dependent reporter labeling in the deeper dorsal horn is not due to transient cre expression during development.

(A, B) The pattern of tdTomato expression driven by Gucy2d-cre when crossed to the Ai9 reporter mouse line (A) was similar to tdTomato expression driven by Gucy2d-cre after intraspinal injections of AAV8-CAG-FLEX-tdTomato viral vector in adulthood (B ...
Judy J. Yoo (18155545), Elizabeth K. Serafin (18155542), Xinzhong Dong (350603), Mark L. Baccei (11174745), Jie Li (15030)   +4 more
core   +1 more source

Cre-dependent monosynaptic rabies tracing reveals local and distant circuit input connections to CA3a, CA3b, and CA3c subregions.

, 2021
(A–F) Example images showing monosynaptic rabies virus–labeled neurons in presynaptic input regions. Presynaptic cells are found in the MS, the VDB of Broca (A1 to A3), the HDB of Broca (B1 and B2), ventral CA3, the GrDG (C1 to C3), RM nucleus (D1 and D2)
Michelle Amalraj (11859112), Todd C. Holmes (11859121), Douglas A. Nitz (11859124), Xiaoxiao Lin (1540957), Brenda Avila (11859118), Crisylle Blanton (11859115), Xiangmin Xu (195070)   +6 more
core   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

CRE Financial Council Compendium of Statistics

, 2011
This document depicts the CRE Finance Council\u27s breakdown of CMBS and CMBX ...
CRE Finance Council (CREFC)
core   +1 more source