Results 241 to 250 of about 339,433 (382)

Feasibility of Simon Two‐Stage Futility Trials in People with Early, Symptomatically Treated Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Disease‐modifying treatments are a critical unmet need in Parkinson's disease (PD). Phase 2 futility trials using the Simon two‐stage design offer an efficient strategy to evaluate candidate treatments in an early PD population. Objective The aim was to assess the feasibility of Simon two‐stage futility trials in early, levodopa ...
Marcus W. Koch, Lorraine V. Kalia, Justyna Sarna, Camila Aquino, Daryl Wile, Tiago A. Mestre, Michael G. Schlossmacher, Miguel D'Haeseleer, Jop Mostert, Eva M.M. Strijbis, Bernard Uitdehaag, Tarrant McPherson, Gary Cutter   +12 more
wiley   +1 more source

Exploring the Potential Impact of Creatine Supplementation on Anesthetic Outcomes: A Comprehensive Review. [PDF]

Cureus
Lehmeidi Y, Beck Neto T.
europepmc   +1 more source

A Mediterranean Diet‐Based Food Mix Ameliorates Diabetes‐ and Obesity‐Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming

Molecular Nutrition &Food Research, EarlyView.
Metabolic syndrome (MetS)‐related conditions are key factors in liver damage. A Mediterranean lifestyle shows promise in managing MetS, though its mechanisms remain unclear. This study tested a lab‐designed food mix mimicking the 1960s Mediterranean Diet (MD) on obese and diabetic mice; it prevented hyperlipidemia and reduced oxidative liver damage ...
Giovanna Mercurio, Antonia Giacco, Antonio Dario Troise, Moira Ledbetter, Sabrina De Pascale, Nicla Scopigno, Michela Vigliotti, Matteo Mazzola, Giuseppe Riccio, Andrea Scaloni, Maria Moreno, Alberto Fiore, Federica Cioffi, Elena Silvestri   +13 more
wiley   +1 more source

Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT). [PDF]

Proc Natl Acad Sci U S A
Yuan X, Yin J, Liu C, Chen X, Chen M, Wang Y, Yang Z, Wang Y, Jiang L, Zhou N, Wang X, Liu B, Ma Z, Wang K, Li H, Zhang S, Shang Y, Yang M.   +17 more
europepmc   +1 more source

Bioavailability of Magnesium and Potassium Salts Used as Potential Substitutes for Sodium Chloride in Human Nutrition — A Review

Molecular Nutrition &Food Research, EarlyView.
A high intake of sodium chloride contributes to hypertension. This review evaluates the bioavailability of potassium and magnesium salts as sodium chloride alternatives. Potassium chloride and citrate, as well as magnesium citrate and chloride, show good absorption.
Ronja Merschmann, Carlotta Burgmer, Gunter P. Eckert, Anika E. Wagner   +3 more
wiley   +1 more source

Relationship between creatine kinase and gastric cancer: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Tu Y, Xie D, Qian H.
europepmc   +1 more source

Absolute quantification of cerebral metabolites using two‐dimensional proton MR spectroscopic imaging with quantitative MRI‐based water reference

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose Metabolite concentrations are valuable biomarkers in brain tumors (BTs). However, absolute quantification of metabolites using MR spectroscopy requires a correction of water relaxation using time‐consuming quantitative MRI (qMRI) sequences in addition to a lengthy two‐dimensional spectroscopic water‐reference acquisition.
Dennis C. Thomas, Seyma Alcicek, Andrei Manzhurtsev, Elke Hattingen, Katharina J. Wenger, Ulrich Pilatus   +5 more
wiley   +1 more source

CREATININE AND CREATINE IN MUSCLE EXTRACTS

, 1921
Frederick S. Hammett
openalex   +1 more source

INTERRELATIONS OF MAGNESIUM, POTASSIUM, PHOSPHORUS, AND CREATINE IN SKELETAL MUSCLE OF MAN 1 [PDF]

, 1952
David M. Baldwin, Peter Robinson, Kenneth L. Zierler, J. L. Lilienthal   +3 more
openalex   +1 more source

A data‐driven algorithm to determine 1H‐MRS basis set composition

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose Metabolite amplitude estimates derived from linear combination modeling of MR spectra depend on the precise list of constituent metabolite basis functions used (the “basis set”). The absence of clear consensus on the “ideal” composition or objective criteria to determine the suitability of a particular basis set contributes to the poor
Christopher W. Davies‐Jenkins, Helge J. Zöllner, Dunja Simicic, Seyma Alcicek, Richard A. E. Edden, Georg Oeltzschner   +5 more
wiley   +1 more source