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Creatine transporters: A reappraisal

Molecular and Cellular Biochemistry, 2004
Creatine (Cr) plays a key role in cellular energy metabolism and is found at high concentrations in metabolically active cells such as skeletal muscle and neurons. These, and a variety of other cells, take up Cr from the extra cellular fluid by a high affinity Na(+)/Cl(-)-dependent creatine transporter (CrT). Mutations in the crt gene, found in several
Speer, Oliver   +7 more
openaire   +4 more sources

Brain Creatine Kinase and Creatine Transporter Proteins in Normal and Creatine-Treated Rabbit Pups

Developmental Neuroscience, 2000
Systemic creatine (Cr) supplementation increases brain phosphocreatine (PCr) and prevents hypoxic seizures in 15-day-old rabbits . Between 5 and 30 days of age during normal development, rabbit gray matter mitochondrial creatine kinase (Mi-CK) increases 400% while cytosolic CK (BB-CK) increases 60%.
David M. Holtzman   +3 more
openaire   +3 more sources

Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis.

Journal of renal nutrition, 2019
Creatine supplements are intended to improve performance, but there are indications that it can overwhelm liver and kidney functions, reduce the quality of life, and increase mortality.
Alexandre de Souza E Silva   +7 more
semanticscholar   +1 more source

Creatine and Creatine Deficiency Syndromes: Biochemical and Clinical Aspects

Pediatric Neurology, 2010
Creatine deficiency syndromes, which have only recently been described, represent a group of inborn errors of creatine synthesis (L-arginine-glycine amidinotransferase deficiency and guanidinoacetate methyltransferase deficiency) and transport (creatine transporter deficiency). Patients with creatine deficiency syndromes present with mental retardation
Fahmi Nasrallah   +2 more
openaire   +2 more sources

A method for the determination of creatine in blood serum with creatine phosphokinase

Clinica Chimica Acta, 1966
Abstract A method is described for the determination of creatine in blood serum with creatine phosphokinase on the principles of that of Tanzer and Gilvarg 1 . Serum is treated with a solution of iodine and then protein is removed with barium hydroxide and zinc sulfate.
A.T. Milhorat, A.C. Kibrick
openaire   +3 more sources

Creatine deficiency syndromes

Molecular and Cellular Biochemistry, 2003
Since the first description of a creatine deficiency syndrome, the guanidinoacetate methyltransferase (GAMT) deficiency, in 1994, the two further suspected creatine deficiency syndromes--the creatine transporter (CrT1) defect and the arginine:glycine amidinotransferase (AGAT) deficiency were disclosed.
openaire   +4 more sources

Irreversible brain creatine deficiency with elevated serum and urine creatine: A creatine transporter defect?

Annals of Neurology, 2001
AbstractRecent reports highlight the utility of in vivo magnetic resonance spectroscopy (MRS) techniques to recognize creatine deficiency syndromes affecting the central nervous system (CNS). Reported cases demonstrate partial reversibility of neurologic symptoms upon restoration of CNS creatine levels with the administration of oral creatine.
Cornelis Jakobs   +7 more
openaire   +3 more sources

Creatine and creatinine metabolism.

Physiological Reviews, 2000
M. Wyss, R. Kaddurah-Daouk
semanticscholar   +1 more source

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