Results 81 to 90 of about 339,433 (382)
Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks
Advanced Functional Materials, EarlyView.This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson +12 more
wiley +1 more source
On the role of the oxidation in the methylation of guanidoacetic acid [PDF]
, 1947 There are two, at least, methyl transfer reactions promoted by liver slices in vitro (2).
Borsook, Henry, Dubnoff, Jacob W.
core
Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME
Advanced Functional Materials, EarlyView.A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li +10 more
wiley +1 more source
Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity
Nature Metabolism, 2019 Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis reduces thermogenesis and causes obesity. However, whether creatine import from the circulation affects adipocyte thermogenesis is unknown. Here we show that deletion
L. Kazak +15 more
semanticscholar +1 more source
ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing
Advanced Healthcare Materials, EarlyView.A reactive oxygen species (ROS) scavenging and immunomodulatory microneedle patch based on hyaluronic acid methacrylate (HaMA) and Flightless I (Flii)‐siRNA‐laden arginine functionalized poly (β‐amino ester)/alginate particles is developed for chronic wound healing applications.
Mahshid Kharaziha +4 more
wiley +1 more source
Magnetic Resonance Spectroscopy in Diagnosing Brain Tumours? Is it Worth Doing [PDF]
International Journal of Anatomy Radiology and Surgery, 2019 Introduction: Magnetic Resonance Spectroscopy (MRS) is a non-invasive diagnostic method useful in providing information about specific metabolites in brain tissue that can indicate the presence of tumour, necrotic tissue and other pathologic entities.
Sunita Dashottar +1 more
doaj +1 more source
Technical pre-analytical effects on the clinical biochemistry of Atlantic salmon (Salmo salar L.) [PDF]
, 2016 Clinical biochemistry has long been utilized in human and veterinary medicine as a vital diagnostic tool, but despite occasional studies showing its usefulness in monitoring health status in Atlantic salmon (Salmo salar L.), it has not yet been widely ...
Ashby, A. +6 more
core +1 more source
Advanced Healthcare Materials, EarlyView.The emerging field of MXene/MBene materials has progressed rapidly, advancing diverse research fields, including biomedical engineering, biomedicine, agriculture, and the environment. This nanobiotechnology can tackle longstanding challenges in these areas.
Alireza Rafieerad, Ahmad Amiri
wiley +1 more source
Experimental PhysiologyThe effect of biological sex on rates of skeletal muscle mitochondrial respiration supported by creatine‐dependent phosphate shuttling was previously unknown.
Emily J. Ferguson +11 more
doaj +1 more source
HUMAN IMMUNE SYSTEM AND PHYSICAL EXERCISE
Медицинская иммунология, 2014 . Physiological and biochemical changes proceeding in muscles during physical loads exert systemic influence upon protein biosynthesis. This process is accelerated in presence of free amino acids, sufficient quantities of hormones, creatine, hydrogen ...
Z. Ch. Musin, S. V. Latukhov
doaj +1 more source