Results 91 to 100 of about 1,032,826 (402)

Vergleich dreier Ringversuche zur radioimmunologischen Thyrotropin-Bestimmung nach dem "Münchner Modell" [PDF]

, 1983
Peer ...
Habermann, J., König, A., Marschner, I., Scriba, Peter Christian, van Thiel, D., Wood, W. G.   +5 more
core   +2 more sources

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, EarlyView.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression

Advanced Science, EarlyView.
Cancer‐associated fibroblast (CAF)‐derived VTN upregulates SLC6A8 expression in colorectal cancer (CRC) cells and macrophages through enhanced FAK phosphorylation. This modulation significantly increases the cellular uptake of creatine and ATP, promoting cancer progression and macrophage polarization.
Jiahua Yu, Mengxi Xiu, Shijun Yu, Zhiqin Chen, Yandong Li, Yong Gao   +5 more
wiley   +1 more source

Creatine Kinase Activity and Malondialdehyde in the Seminal Plasma of Normospermic Infertile Males

مجلة كلية الطب, 2009
Background: Normospermia might be a major problem to the doctor and the infertile couple because the male seminal sample has an accepted seminal parameters during the routine seminal examination and the female partner will be claimed for the infertility ...
Ghassan T. Alani, Hedef D. El Yaseen
doaj   +1 more source

Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor

Nature Chemical Biology, 2023
Narek Darabedian, Wenzhi Ji, Mengyang Fan, Shan Lin, H. Seo, E. Vinogradova, Tomer M. Yaron, E. Mills, Haopeng Xiao, Kristine Senkane, Emily M Huntsman, Jared L. Johnson, Jianwei Che, L. Cantley, B. Cravatt, S. Dhe-Paganon, K. Stegmaier, Tinghu Zhang, N. Gray, Edward T. Chouchani   +19 more
semanticscholar   +1 more source

A Novel Class of Multi‐substituted Diaryl Scaffold Derivatives Inhibit Glioblastoma Progression by Targeting CD155

Advanced Science, EarlyView.
Structural modification of clofoctol yielded a novel blood‐brain barrier‐permeable compound, B7, featuring a multi‐substituted diaryl scaffold. B7 demonstrates potent anti‐glioblastoma activity by suppressing glioblastoma stem cells proliferation, migration, and invasion through interactions with five key residues of poliovirus receptor cell adhesion ...
Yong‐jian Wang, Ting Sun, Si‐tu Xue, Zhong‐di Cai, Hong Yi, Miao Lv, Shi‐bo Kou, Rui Liu, Xiao‐zhong Peng, Zhuo‐rong Li   +9 more
wiley   +1 more source

Efek Paparan Arus Listrik terhadap Jumlah Titik Hiperkontraksi Otot Jantung dan Kadar Kreatin Kinase - MB Serum Tikus Wistar [PDF]

, 2011
Background: Electrocution can cause damages in tissue and body biochemical changes including heart muscles hypercontraction and elevation of creatine kinase–MB serum level.
Relawati, Ratna
core  

Muscle Cramping During a 161-km Ultramarathon: Comparison of Characteristics of Those With and Without Cramping [PDF]

, 2015
Background: This work sought to identify characteristics differing between those with and without muscle cramping during a 161-km ultramarathon. Methods: In this observational study, race participants underwent body weight measurements before, during ...
Hoffman, Martin D., Stuempfle, Kristin J.   +1 more
core   +3 more sources

Creatine kinase B controls futile creatine cycling in thermogenic fat

Nature, 2021
Janane F. Rahbani, Anna Roesler, M. F. Hussain, B. Samborska, Christien B. Dykstra, Linus T. Tsai, Mark P. Jedrychowski, L. Vergnes, K. Reue, B. Spiegelman, L. Kazak   +10 more
semanticscholar   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source