Results 221 to 230 of about 169,068 (339)

Activation of cGAS‐STING Pathway by DAI‐Triggered Ferroptosis in CRC Cells Reprograms TAMs Balance to Promote Anti‐Tumor Immunity

open access: yesCancer Science, EarlyView.
Our study identified and preliminarily elucidated the ferroptosis‐induced cGAS‐STING‐mediated anti‐tumor pathway triggered by DAI in colorectal cancer cells, providing new insight into the role of PCD in anti‐tumor immunotherapy and screening out potential targets for the treatment of colorectal cancer.
Pengrui Cheng   +4 more
wiley   +1 more source

Metabolic Syndrome and Insulin Resistance Are Associated With Normal‐Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Aim To determine whether metabolic syndrome (MS), insulin resistance (IR), myocardial enzymes, and kidney function are related to the normal‐range of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and their ratio in Chinese women with polycystic ovary syndrome (PCOS).
Jiaxing Feng   +8 more
wiley   +1 more source

Phosphocreatine Rescues Intestinal Epithelial Metabolic Dysfunction Related to Creatine Kinase Loss and Is Protective in Murine Colitis. [PDF]

open access: yesCell Mol Gastroenterol Hepatol
Bhagavatula G   +8 more
europepmc   +1 more source

High Concordance of Copy Number Variants Detected by Chromosomal Microarray and Exome Sequencing in Clinical Diagnostics

open access: yesClinical Genetics, EarlyView.
To assess the relevance of exome sequencing as a first‐tier diagnostic tool, three aspects were investigated: detection of copy number variants (CNVs) from exomes as compared to chromosomal microarray, clinically‐relevant CNVs across all sizes, and additional diagnostic utilities (uniparental disomy and triploidy).
Rivka Birnbaum   +13 more
wiley   +1 more source

Repurposing colchicine for reduction of residual inflammatory risk in type 1 diabetes: Design and rationale of the REC1TE trial

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Compared to people without diabetes, individuals with type 1 diabetes have a several‐fold increased risk of cardiovascular (CV) morbidity and mortality despite guideline‐recommended management of traditional risk factors; so‐called residual CV risk.
David S. Mathiesen   +13 more
wiley   +1 more source

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