Results 261 to 270 of about 1,019,575 (429)

Clinical modeling of motor function to predict treatment efficacy and enable in silico treatment comparisons in infantile‐onset Pompe disease

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
Abstract Infantile‐onset Pompe disease (IOPD) is a rare, deadly, quickly‐progressing degenerative disease. Even with life‐sustaining treatment (e.g., alglucosidase alfa [ALGLU]), many patients experience continued motor impairment. The Mini‐COMET trial evaluated avalglucosidase alfa (AVAL) versus ALGLU on motor and other outcomes in IOPD.
Fatiha Rachedi   +6 more
wiley   +1 more source

Microscope‐Free Analyte Detection Based on Fiber‐Optic Gliding Motility Assays

open access: yesSmall, EarlyView.
Lab‐on‐fiber technology enables rapid, cost‐effective, and in situ analyte detection, addressing critical gaps in point‐of‐care diagnostics. This study presents a microscope‐free biosensor that utilizes motor‐protein‐driven microtubules on optical fibers to detect biomarkers like Creatine Kinase‐MB. By tracking gliding speed changes, it offers a novel,
Henry Carey‐Morgan   +4 more
wiley   +1 more source

Paliperidone-Induced Massive Asymptomatic Creatine Kinase Elevation in Youth: From a Case Report to Literature Review. [PDF]

open access: yesPediatr Rep
Grandioso A   +8 more
europepmc   +1 more source

ENT‐1‐Targeted Polymersomes to Enhance the Efficacy of Methotrexate in Choriocarcinoma Treatment

open access: yesSmall Science, EarlyView.
ENT‐1‐targeted stimuli‐responsive polymersomes enhance the delivery and release of MTX, as demonstrated in choriocarcinoma tumors mouse model. These targeted nanocarriers improve tumor uptake and efficiently release the drug within the tumor, highlighting their potential for enhanced chemotherapy in choriocarcinoma treatment.
Babak Mamnoon   +10 more
wiley   +1 more source

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