Results 71 to 80 of about 169,068 (339)

SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

Cell Reports
Summary: Tumor metabolic reprogramming is critical for providing energy to support proliferation and resistance to stress-induced cell death. However, the regulatory mechanisms linking these processes remain incompletely understood.
Xiaojun Zhou, Genxin Wang, Yuhang Wu, Mingzhi Wu, Xiang Zhai, Chenhui Tian, Edward V. Prochownik, Congqing Jiang, Youjun Li   +8 more
doaj   +1 more source

The Effect of Dry Cupping Therapy and Creatine Supplementation on Lactic Acid, Lactate Dehydrogenase and Creatine Kinase in Plasma Following Wingate Anaerobic Test in Male Handball Players

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2022
Objective Optimum recovery can prevent the athlete's functional capacity from falling between training sessions or competitions. The aim of this study was to evaluate the effect of dry cupping therapy and creatine supplementation on lactic acid, lactate ...
Faiza Mohammad Qoliha, Khadijeh Irandoust, Mortaza Taheri, Maghsoud Nabilpour   +3 more
doaj  

Multisystem proteinopathy due to a homozygous p.Arg159His VCP mutation : a tale of the unexpected [PDF]

, 2020
ObjectiveTo assess the clinical, radiologic, myopathologic, and proteomic findings in a patient manifesting a multisystem proteinopathy due to a homozygous valosin-containing protein gene (VCP) mutation previously reported to be pathogenic in the ...
Azmi, A, Baets, J, Clemen, CS, De Bleecker, Jan, De Jonghe, P, De Ridder, W, Eichinger, L, Hofmann, A, Johnson, K, Maudsley, S, Schröder, R, Straub, V, Töpf, A   +12 more
core   +1 more source

Nanoparticle‐Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy

Advanced Science, EarlyView.
This study presents a nanoparticle‐embedded nanofiber (5F/STFM/R‐ES) to inhibit melanoma growth and reduce the risk of metastasis and recurrence. The drug delivery system induces ferroptosis and potentiates immunotherapy through resiquimod (R848) and Fe/Mn‐based metal‐polyphenol networks (TFM).
Mingyang Li, Rongrong Li, Baotong Xu, Yuhan Lian, Chenyu Yang, Jingwen Li, Junhao Liang, Linhan Ding, Dongsheng Zhang, Jing Guo, Xiao Fu   +10 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Both Creatine and Its Product Phosphocreatine Reduce Oxidative Stress and Afford Neuroprotection in an Parkinson’s Model

ASN Neuro, 2014
Creatine is the substrate for creatine kinase in the synthesis of phosphocreatine (PCr). This energetic system is endowed of antioxidant and neuroprotective properties and plays a pivotal role in brain energy homeostasis. The purpose of this study was to
Mauricio Peña Cunha, Maria D. Martín-de-Saavedra, Alejandro Romero, Javier Egea, Fabiana K. Ludka, Carla I. Tasca, Marcelo Farina, Ana Lúcia S. Rodrigues, Manuela G. López   +8 more
doaj   +1 more source

Smad7:β-catenin Complex Regulates Myogenic Gene Transcription [PDF]

, 2019
Recent reports indicate that Smad7 promotes skeletal muscle differentiation and growth. We previously documented a non-canonical role of nuclear Smad7 during myogenesis, independent of its role in TGF-β signaling.
McDermott, John, Tetsuake, Miyake, Tripathi, Soma   +2 more
core   +1 more source

Regulation of Creatine Kinase by ASB9 [PDF]

Biophysical Journal, 2014
Creatine kinases (CKs) regulate ATP levels at sites of fluctuating energy demands. Reduced CK activity has been implicated in diseases such as heart failure and multiple sclerosis, however little is known about CK regulation. Ankyrin repeat and SOCS box-containing protein, ASB9, (part of an E3 ubiquitin ligase) has been shown to promote proteasomal ...
Elizabeth A. Komives, Jamie M. Schiffer, Deepa Balasubramaniam   +2 more
openaire   +2 more sources

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

Advanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang, Wenye Wang, Yidong Peng, Weiji Weng, Hanyu Wei, Qiyuan Feng, Antian Wang, Minjie Hu, Zhuoran Li, Shenyu Sun, Zhenghui He, Daiwen Zhang, Wenlan Qi, Yuhan Han, Zixuan Ma, Jiyuan Hui, Ru Gong, Yingwei Gao, Yong Lin, Jiyao Jiang, Xiaoling Gao, Junfeng Feng   +21 more
wiley   +1 more source

Increased postictal creatine kinase in epilepsy patients

Эпилепсия и пароксизмальные состояния
Excessive muscle activity during generalized convulsive seizures in epilepsy patients in some cases can cause significant changes in blood plasma biochemical parameters, increased level of a set of metabolites, particularly, serum creatine kinase ...
L. V. Lipatova, I. V. Sakovsky
doaj   +1 more source