Results 241 to 250 of about 15,296 (267)

Functional Insights into the Creatine Transporter

2007
Creatine and phosphocreatine provide an intracellular, high-energy phosphate buffering system, essential to maintain ATP levels in tissues with high energy demands. A specific plasma membrane creatine transporter (CRT) is required for the cellular uptake of creatine.
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Creatine Transporter Deficiency

2011
Abstract XLID caused by cerebral creatine deficiency with decreased muscle mass, hypotonia, expressive language impairment, seizures, and aberrant behavior. Mutations in the solute transporter SLC6A8 are the cause and may represent one of the most common causes of XLID (1–3%).
Roger E. Stevenson, Charles E. Schwartz, R. Curtis Rogers   +2 more
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Materno-Fetal Transport of Creatine in the Rat

Biology of the Neonate, 2009
The transfer of 14C-creatine to the rat fetus was studied following continuous i.v. infusion into the mother. In the presence of a relatively constant maternal plasma 14C-creatine concentration, creatine was accumulated by the chorioallantoic placenta and visceral yolk sac to concentrations higher than that found in maternal or fetal plasma.
B M, Davis, R K, Miller, R L, Brent, T R, Koszalka   +3 more
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Downregulation of the Creatine Transporter SLC6A8 by JAK2

The Journal of Membrane Biology, 2012
Janus-activated kinase-2 (JAK2) participates in the regulation of the Na⁺-coupled glucose transporter SGLT1 and the Na⁺-coupled amino acid transporter SLC6A19. Concentrative cellular creatine uptake is similarly accomplished by Na⁺-coupled transport. The carrier involved is SLC6A8 (CreaT).
Manzar, Shojaiefard, Zohreh, Hosseinzadeh, Shefalee K, Bhavsar, Florian, Lang   +3 more
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The Cloning and Expression of a Human Creatine Transporter

Biochemical and Biophysical Research Communications, 1994
A human creatine transporter (hCRT-BS2M) cDNA clone was isolated from a human brainstem/spinal cord using a PCR and phage plaque hybridization based technique. This clone included an open reading frame of 1,905 base pairs(bp) within a 2,283bp cDNA.
I. Sora, J. Richman, G. Santoro, H.B. Wei, Y. Wang, T. Vanderah, R. Horvath, M. Nguyen, S. Waite, W.R. Roeske, H.I. Yamamura   +10 more
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Creatine biosynthesis and transport in health and disease

Biochimie, 2015
Creatine is physiologically provided equally by diet and by endogenous synthesis from arginine and glycine with successive involvements of arginine glycine amidinotransferase [AGAT] and guanidinoacetate methyl transferase [GAMT]. A specific plasma membrane transporter, creatine transporter [CRTR] (SLC6A8), further enables cells to incorporate creatine ...
Joncquel-Chevalier Curt, M., Voicu, P. M., Fontaine, M., Dessein, A. F., Porchet, N., Mention-Mulliez, K., Dobbelaere, D., Soto-Ares, G., Cheillan, David, Vamecq, J.   +9 more
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The clinical syndrome of creatine transporter deficiency

Molecular and Cellular Biochemistry, 2003
To describe the clinical, spectroscopic and neuropsychological features of the first family diagnosed with a defect in the creatine transporter. Proton Magnetic Resonance Spectroscopy (MRS) indicated an absence of creatine and phosphocreatine in the brain of a male patient characterized by developmental delay, mild epilepsy and severe expressive ...
Ton J, deGrauw, Kim M, Cecil, Anna W, Byars, Gajja S, Salomons, William S, Ball, Cornelis, Jakobs   +5 more
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Creatine and guanidinoacetate: diagnostic markers for inborn errors in creatine biosynthesis and transport

Molecular Genetics and Metabolism, 2004
In this study, measurements of guanidinoacetate (GAA) and creatine (Cr) in urine, plasma, and cerebrospinal fluid (CSF) were performed using stable isotope dilution gas chromatography-mass spectrometry. Both compounds were analyzed in a single analysis. Reference values were established for GAA and Cr. These values were age dependent.
Lígia S, Almeida, Nanda M, Verhoeven, Birthe, Roos, Carla, Valongo, Maria Luis, Cardoso, Laura, Vilarinho, Gajja S, Salomons, Cornelis, Jakobs   +7 more
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The expression of creatine transporters is regulated by creatine and differentiation

Journal of Molecular and Cellular Cardiology, 1987
J LOIKE, E KABACK, S SILVERSTEIN
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Functional characterization of monocarboxylate transporter 12 (SLC16A12/MCT12) as a facilitative creatine transporter

Drug Metabolism and Pharmacokinetics, 2020
Hisanao Kishimoto, Yoshiyuki Shirasaka, Katsuhisa Inoue   +2 more
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