Results 231 to 240 of about 15,296 (267)

Creatine and the creatine transporter: A review

Molecular and Cellular Biochemistry, 2001
The cellular role of creatine (Cr) and Cr phosphate (CrP) has been studied extensively in neural, cardiac and skeletal muscle. Several studies have demonstrated that alterations in the cellular total Cr (Cr + CrP) concentration in these tissues can produce marked functional and/or structural change.
Snow, Rodney., Murphy, Robyn Maree.
openaire   +2 more sources

Creatine transporters: A reappraisal

Molecular and Cellular Biochemistry, 2004
Creatine (Cr) plays a key role in cellular energy metabolism and is found at high concentrations in metabolically active cells such as skeletal muscle and neurons. These, and a variety of other cells, take up Cr from the extra cellular fluid by a high affinity Na(+)/Cl(-)-dependent creatine transporter (CrT). Mutations in the crt gene, found in several
Speer, Oliver, Neukomm, Lukas, Murphy, Robyn, Zanolla, Elsa, Schlattner, Uwe, Henry, Hugues, Snow, Rodney, Wallimann, Theo   +7 more
openaire   +4 more sources

Disorders of creatine transport and metabolism

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 2011
AbstractCreatine is a nitrogen containing compound that serves as an energy shuttle between the mitochondrial sites of ATP production and the cytosol where ATP is utilized. There are two known disorders of creatine synthesis (both transmitted as autosomal recessive traits: arginine: glycine amidinotransferase (AGAT) deficiency; OMIM 602360; and ...
Nicola, Longo, Orly, Ardon, Rena, Vanzo, Elizabeth, Schwartz, Marzia, Pasquali   +4 more
openaire   +2 more sources

Dodecyl creatine ester, a promising treatment to deliver creatine to neurons, achieves pharmacology efficacy in creatine transporter deficiency

European Journal of Medicinal Chemistry
International audienceDodecyl creatine ester (DCE) is a creatine prodrug currently developed for brain diseases, including creatine transporter deficiency (CTD), an incurable rare genetic disease.
Clemence Disdier, Anne-Cécile Guyot, Narciso Costa   +2 more
exaly   +2 more sources

Muscle creatine uptake and creatine transporter expression in response to creatine supplementation and depletion

Journal of Applied Physiology, 2003
The total creatine pool size [Crtotal; creatine (Cr) + phosphocreatine (PCr)] is crucial for optimal energy utilization in skeletal muscle, especially at the onset of exercise and during intense contractions. The Crtotallikely is controlled by long-term modulation of Cr uptake via the sodium-dependent Cr transporter (CrT).
Jeffrey J, Brault, Kirk A, Abraham, Ronald L, Terjung   +2 more
openaire   +2 more sources

Myocellular Creatine and Creatine Transporter Serine Phosphorylation after Starvation

Journal of Surgical Research, 2002
Myocellular creatine, which is critically important for normal energy metabolism, increases in rat gastrocnemius muscle after starvation via unknown mechanisms. Creatine (Cr) uptake across plasma membranes is governed by a single, specific transporter (CrTr) that shares 50% amino acid sequence identity with GABA/choline/betaine transporters whose ...
Chun-Rui, Zhao, Lihong, Shang, Weiyang, Wang, Danny O, Jacobs   +3 more
openaire   +2 more sources

The Creatine-Creatine Phosphate Shuttle for Energy Transport — Compartmentation of Creatine Phosphokinase in Muscle

1982
There are two viewpoints regarding the role of the enzyme creatine Phosphokinase (CPK), which catalyzes the reversible transphosphorylation of creatine and adenine nucleotides in energy transport. The classical viewpoint (Fig. 1) regards CPK as a near equilibrium enzyme buffering cytosolic changes in nucleotide concentration (1,2), with creatine ...
S, Erickson-Viitanen, P, Geiger, W C, Yang, S P, Bessman   +3 more
openaire   +2 more sources

Response to creatine analogs in fibroblasts and patients with creatine transporter deficiency

Molecular Genetics and Metabolism, 2010
Creatine transporter (CRTR) deficiency is one of the most frequent causes of X-linked mental retardation. The lack of an effective treatment for this disease, in contrast to creatine (Cr) biosynthesis disorders that respond to Cr monohydrate (CM), led us to analyze the efficacy of a lipophilic molecule derived from Cr, creatine ethyl ester (CEE), in ...
Fons C, Arias A, Sempere A, Póo P, Pineda M, Mas A, López-Sala A, Garcia-Villoria J, Vilaseca MA, Ozaez L, Lluch M, Artuch R, Campistol J, Ribes A   +13 more
openaire   +3 more sources

Irreversible brain creatine deficiency with elevated serum and urine creatine: A creatine transporter defect?

Annals of Neurology, 2001
AbstractRecent reports highlight the utility of in vivo magnetic resonance spectroscopy (MRS) techniques to recognize creatine deficiency syndromes affecting the central nervous system (CNS). Reported cases demonstrate partial reversibility of neurologic symptoms upon restoration of CNS creatine levels with the administration of oral creatine.
K M, Cecil, G S, Salomons, W S, Ball, B, Wong, G, Chuck, N M, Verhoeven, C, Jakobs, T J, DeGrauw   +7 more
openaire   +2 more sources

Brain Creatine Kinase and Creatine Transporter Proteins in Normal and Creatine-Treated Rabbit Pups

Developmental Neuroscience, 2000
Systemic creatine (Cr) supplementation increases brain phosphocreatine (PCr) and prevents hypoxic seizures in 15-day-old rabbits . Between 5 and 30 days of age during normal development, rabbit gray matter mitochondrial creatine kinase (Mi-CK) increases 400% while cytosolic CK (BB-CK) increases 60%.
T, Kekelidze, I, Khait, A, Togliatti, D, Holtzman   +3 more
openaire   +2 more sources