Results 211 to 220 of about 15,296 (267)

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Interpretation of Chemistry, Hematology and Coagulation Laboratory Results in Early‐Phase Clinical Pharmacology Trials; a Retrospective Analysis Based on the Placebo Arm of Randomized‐Controlled Trials

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Early‐phase clinical trials focus heavily on demonstrating safety and tolerability of drug candidates. Clinical laboratory test results outside of reference intervals (RIs) are often interpreted as possible indicators of harm. However, values outside RIs do not necessarily constitute drug‐induced adverse effects.
Jannik Rousel, Tessa Niemeyer‐van der Kolk, Matthijs Moerland, Robert Rissmann, Naomi B. Klarenbeek, Maurits F. J. M. Vissers, Jacobus Burggraaf   +6 more
wiley   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Obstructive sleep apnoea is associated with accelerated progression of diabetic kidney disease

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Aim Persons with type 2 diabetes and diabetic kidney disease (DKD) are at high risk of end‐stage kidney disease or death. We investigated the possible contribution of obstructive sleep apnoea (OSA) to decline in kidney function and renal outcomes.
Sebastian Nielsen, Martin B. Thomsen, Jakob Nyvad, Esben Laugesen, Erik Lerkevang Grove, Per Løgstrup Poulsen, Kent Lodberg Christensen, Mads Vaarby Sørensen, Peder Berg, Niels Henrik Buus   +9 more
wiley   +1 more source

Integrative Advances in Equine Genomics From Reference Assemblies to Evolutionary History and Key Traits

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT Horses are major domestic animals and cultural symbols that have accompanied humans for millennia. They underpin transport, agriculture, warfare and sport, and also provide a model for studying domestication, complex traits and adaptive evolution.
Ying Lu, Ruoshan Ma, Bo Wang, Jiao Wu, Yuqing Chong, Zhendong Gao, Weidong Deng   +6 more
wiley   +1 more source

Connectomic and behavioral alterations in creatine transporter deficiency are partially normalized by gene therapy

Montani C, Iovino L, Vetta FD, Pasquin Mariani JR, De Guzman AE, Gini S, Galbusera A, D’Epifanio B, Ghirardini E, Cornuti S, Dadà L, Putignano E, Alessandrì MG, Vasirani G, Bertozzi SM, Armirotti A, Baroncelli L, Gozzi A.   +17 more
europepmc   +1 more source

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, Volume 293, Issue 12, Page 3663-3682, June 2026.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

RESPONSE TO CREATINE ANALOGOUS SUPPLEMENTATION IN CREATINE TRANSPORTER DEFICIENCY

, 2009
Campistol-Plana J, Fons-Estupina C, Arias AY, Poo P, López-Sala A, Mas A, Ribes A, Artuch-Iriberri R   +7 more
openaire   +2 more sources

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source