Results 191 to 200 of about 15,296 (267)

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1196-1205, June 2026.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Rescue of myocytes and locomotion through AAV2/9-2YF intracisternal gene therapy in a rat model of creatine transporter deficiency. [PDF]

Mol Ther Methods Clin Dev
Fernandes-Pires G, Azevedo MD, Lanzillo M, Roux-Petronelli C, Binz PA, Cudalbu C, Sandi C, Tenenbaum L, Braissant O.   +8 more
europepmc   +1 more source

Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency. [PDF]

Sci Rep, 2020
Cacciante F, Gennaro M, Sagona G, Mazziotti R, Lupori L, Cerri E, Putignano E, Butt M, Do MT, McKew JC, Alessandrì MG, Battini R, Cioni G, Pizzorusso T, Baroncelli L.   +14 more
europepmc   +1 more source

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Advanced Science, Volume 13, Issue 32, 9 June 2026.
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue, Kaiwen Wu, Bing Wei, Guiling Song, Congyu Sun, Xing Li, Xiangyu Liu, Zhaoxiang Ma, Mingchun Lv, Jasper Landman, Yuan Li   +10 more
wiley   +1 more source

Clinical Profiles and Therapeutic Interventions in Occult Paraquat Poisoning: A Comparative Report of Two Cases

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Delayed diagnosis invariably worsens outcomes in occult paraquat poisoning regardless of exposure route. Implement early urinary screening for suspected cases. Tailor antioxidant and anti‐fibrotic timing to toxicokinetic patterns to mitigate irreversible pulmonary damage.
Minhong Zhao, Shuai Zhou, Ying Zhang, Eryan Yuan, Min Peng, Ying Gao   +5 more
wiley   +1 more source

Chemical optimization of creatine derivatives for the treatment of creatine transporter deficiency

, 2013
Creatine transporter deficiency is a rare brain disease associated with the loss of function of the SLC6A8 (creatine transporter) leading to an absence of creatine at the cerebral level and to a dramatic neurodevelopmental retardation in the children.
openaire   +1 more source

ATOX1 alleviates radiation‐induced cardiac injury by modulating AMPK/NRF2 to inhibit myocardial oxidative stress and mitochondrial dysfunction

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
This study found that ATOX1 can alleviate radiation‐induced oxidative stress and mitochondrial damage, maintain mitochondrial function, and reduce oxidative stress by activating the AMPK/NRF2 signaling pathway, ultimately exerting a cardioprotective effect.
Wen Deng, Li Su
wiley   +1 more source

Hippocampal Glutamatergic Hyperactivation Mediates High‐Loading Intensity of Exercise‐Induced Cognitive Deficits Via HPC‐mPFC Circuit Dysfunction

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
High‐loading intensity of exercise (HLIE) disrupts HPC‐mPFC connectivity and hippocampal activity‐related transcriptomes, mediating cognitive deficits via glutamatergic neuron hyperactivation. Hippocampal glutamatergic neuron hyperactivation drives HLIE‐induced cognitive deficits, while targeted chemogenetic inhibition partly rescues cognitive function.
Qian Bai, Le Wang, Hedong Lang, Hongtao Yu, Xiaolei Wang, Jian Wang, Jundong Zhu, Ka Chen, Mantian Mi   +8 more
wiley   +1 more source

High‐Altitude Hypoxia Activates JNK‐p53 Signaling: Linking Hippocampal Energy Crisis to Cognitive Impairment

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Chronic high‐altitude hypoxia impairs memory in 2819 residents and causes hippocampal atrophy in rats. JNK‐p53‐Bim signaling drives mitophagy‐to‐apoptosis transition and 73% ATP depletion, while concurrent HIF‐2α/PHD2 activation indicates parallel adaptive responses.
Guisheng Hao, Zhengzhong Bai, Wenjuan Wang, Jian Wu, Fan Zheng, Guoen Jin, Ri‐Li Ge   +6 more
wiley   +1 more source

Clinical outcomes of mitochondrial‐enhancing nutraceutical supplementation in psychiatric disorders: A systematic review

General Psychiatry, Volume 39, Issue 3, June 2026.
ABSTRACT Background Nutraceutical supplementation targeting mitochondrial function has been proposed as a beneficial therapeutic strategy to improve physical and mental health in psychiatric patients. Aims To summarise the results of studies evaluating nutraceutical supplementation targeting mitochondrial function in patients with psychiatric disorders.
Juan Tortajada, Bengisu Kevser Bulduk, Belén Alfonso‐Landete, Paula Alcaide‐Barriga, Bernat Ballvé‐Gelonch, Glòria Garrabou, Elisabet Vilella, Yolanda Alonso, Alba Valiente‐Pallejà, Lourdes Martorell   +9 more
wiley   +1 more source