Results 171 to 180 of about 191,979 (223)

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

1H HR‐MAS NMR Metabolomics in Combination With Transcriptomic Correlation Provides New Insights Into Metabolic Heterogeneity Across Breast Cancer Immunohistochemical Subtypes

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Metabolomic profiling of breast cancer tissue using 1H HR‐MAS NMR spectroscopy and LCModel‐based quantitative analysis revealed metabolite differences associated with immunohistochemical subtypes, and subsequent metabolomics–transcriptomics integration linked these subtype‐dependent metabolic signatures to pathways in choline metabolism, one‐carbon ...
Irene Garcia‐Bocanegra, Jesus David Urbano‐Gamez, Antonio Perez‐Cardona, Laura Barrios, Maria Isabel Somoza‐Ramírez, Luis Vicioso, Elena Pardo‐Susacasa, Gema Diaz‐Cordoba, Maria Mercedes Acebal‐Blanco, Francisco Sendra‐Portero, Maria Luisa Garcia‐Martin   +10 more
wiley   +1 more source

Probing binding and occlusion of substrate in the human creatine transporter-1 by computation and mutagenesis. [PDF]

Protein Sci
Clarke A, Farr CV, El-Kasaby A, Szöllősi D, Freissmuth M, Sucic S, Stockner T.   +6 more
europepmc   +1 more source

A Multidisciplinary Approach to the Anesthetic Management of Patients With Duchenne Muscular Dystrophy

Pediatric Pulmonology, Volume 61, Issue 10, October 2026.
ABSTRACT Duchenne muscular dystrophy (DMD) is an inherited neuromuscular disorder with multisystem involvement that causes progressive muscular weakness and cardiorespiratory dysfunction. The first comprehensive recommendations regarding anesthetic management are now almost 20 years old and, in the interval, DMD care has evolved.
Fabrizio Racca, Elena Conti, Giulia Racca, Luigi Barberis, David J. Birnkrant   +4 more
wiley   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad, Niharika Bala, Arooba Illyas, Amir Kazory, Indra Chandrasekar, Abdel A. Alli   +5 more
wiley   +1 more source

Selective Alteration of the Left Arcuate Fasciculus in Two Patients Affected by Creatine Transporter Deficiency. [PDF]

Brain Sci
Balestrino M, Adriano E, Alì PA, Pardini M.   +3 more
europepmc   +1 more source

Restoration of Creatine Transporter Function in a Creatine Transporter Deficient Mouse Model: A Dosage Study

Creatine deficiency syndromes are inborn errors of creatine metabolism, which result in impaired synthesis and transport of creatine. Under normal physiological conditions creatine is synthesized and released into the blood stream to provide cellular ...
Sawilla, Chiara E
core  

Intestinal Epithelial Creatine Transporter SLC6A8 Dysregulation in Inflammation and in Response to Adherent Invasive E. coli Infection. [PDF]

Int J Mol Sci
Sawant H, Selvaraj R, Manogaran P, Borthakur A.   +3 more
europepmc   +1 more source