Heterozygous females from a rat model for creatine transporter deficiency reveal altered behavioral response to stressors, normal body weight and slight metabolic changes [PDF]
Frontiers in NeuroscienceCreatine (Cr) is an organic acid essential for recycling ATP, important in tissues with high energy demand such as muscle or brain. Cr is synthesized in a 2-step pathway by the enzymes AGAT and GAMT, and transported by SLC6A8 (also called CrT).
Lara Duran-Trio +8 more
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Diagnosis and Treatment of X-Linked Creatine Transporter Deficiency: Case Report and Literature Review [PDF]
Brain Sciences, 2023 Sanqing Xu
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Effects of whey isolate, creatine and resistance training on muscle hypertrophy [PDF]
, 2007 PURPOSE: Studies that have attributed gains in lean body mass to dietary supplementation during RE training have not reported these changes alongside adaptations at the cellular and sub-cellular levels. Therefore, the purpose of this study was to examine
Carey, Michael F +4 more
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Transport and inhibition mechanisms of human creatine transporter [PDF]
Cell DiscoveryJiahui Chen +4 more
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Creatine protects against excitoxicity in an in vitro model of neurodegeneration. [PDF]
, 2012 Creatine has been shown to be neuroprotective in aging, neurodegenerative conditions and brain injury. As a common molecular background, oxidative stress and disturbed cellular energy homeostasis are key aspects in these conditions. Moreover, in a recent
Geiger Johanna +17 more
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Urine creatine metabolite panel as a screening test in neurodevelopmental disorders
Orphanet Journal of Rare Diseases, 2020 Background Cerebral creatine deficiency disorders (CCDD) are inherited metabolic disorders of creatine synthesis and transport. Urine creatine metabolite panel is helpful to identify these disorders.
Shalini Bahl +4 more
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Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
Frontiers in Nutrition, 2022 Organisms obtain creatine from their diet or by de novo synthesis via AGAT (L-arginine:glycine amidinotransferase) and GAMT (Guanidinoacetate N-methyltrasferase) in kidney and liver, respectively.
Craig A. Lygate +4 more
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Journal of the International Society of Sports Nutrition, 2006 Creatine monohydrate has become one of the most popular ergogenic sport supplements used today. It is a nonessential dietary compound that is both endogenously synthesized and naturally ingested through diet. Creatine ingested through supplementation has
Greenwood Mike +2 more
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Early Indicators of Creatine Transporter Deficiency [PDF]
Journal of Pediatrics, 2019 Whitney Guthrie +2 more
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Regulation of the Na+,Cl- Coupled Creatine Transporter CreaT (SLC6A8) by the Janus Kinase JAK3
Neurosignals, 2015 Background: The creatine transporter CreaT (SLC6A8), a Na+,Cl- coupled transporter is expressed in diverse tissues including the brain. Genetic defects of SLC6A8 result in mental retardation with seizures.
Myriam Fezai +2 more
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