Results 31 to 40 of about 15,296 (267)

Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine

American Journal of Physiology-Endocrinology and Metabolism, 2003
The intracellular creatine concentration is an important bioenergetic parameter in cardiac muscle. Although creatine uptake is known to be via a NaCl-dependent creatine transporter (CrT), its localization and regulation are poorly understood. We investigated CrT kinetics in isolated perfused hearts and, by using cardiomyocytes, measured CrT content at ...
Boehm, E, Chan, S, Monfared, M, Wallimann, T, Clarke, K, Neubauer, S   +5 more
openaire   +5 more sources

Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. [PDF]

Sci Adv, 2021
Colorectal cancer (CRC) is a leading cause of cancer mortality. Creatine metabolism was previously shown to critically regulate colon cancer progression.
Kurth I, Yamaguchi N, Andreu-Agullo C, Tian HS, Sridhar S, Takeda S, Gonsalves FC, Loo JM, Barlas A, Manova-Todorova K, Busby R, Bendell JC, Strauss J, Fakih M, McRee AJ, Hendifar AE, Rosen LS, Cercek A, Wasserman R, Szarek M, Spector SL, Raza S, Tavazoie MF, Tavazoie SF.   +23 more
europepmc   +2 more sources

Creatine protects against excitoxicity in an in vitro model of neurodegeneration. [PDF]

, 2012
Creatine has been shown to be neuroprotective in aging, neurodegenerative conditions and brain injury. As a common molecular background, oxidative stress and disturbed cellular energy homeostasis are key aspects in these conditions. Moreover, in a recent
Geiger Johanna, Bender Andreas, Klopstock Thomas, Rujescu Dan, Genius, Just, Möller, Hans-Jürgen, Geiger, Johanna, Just Genius, Thomas Klopstock, Johanna Geiger, Klopstock, Thomas, Genius Just, Dan Rujescu, Andreas Bender, Möller Hans-Jürgen, Bender, Andreas, Hans-Jürgen Möller, Rujescu, Dan   +17 more
core   +1 more source

Urine creatine metabolite panel as a screening test in neurodevelopmental disorders

Orphanet Journal of Rare Diseases, 2020
Background Cerebral creatine deficiency disorders (CCDD) are inherited metabolic disorders of creatine synthesis and transport. Urine creatine metabolite panel is helpful to identify these disorders.
Shalini Bahl, Dawn Cordeiro, Lauren MacNeil, Andreas Schulze, Saadet Mercimek-Andrews   +4 more
doaj   +1 more source

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse

Frontiers in Nutrition, 2022
Organisms obtain creatine from their diet or by de novo synthesis via AGAT (L-arginine:glycine amidinotransferase) and GAMT (Guanidinoacetate N-methyltrasferase) in kidney and liver, respectively.
Craig A. Lygate, Hannah A. Lake, Debra J. McAndrew, Stefan Neubauer, Sevasti Zervou   +4 more
doaj   +1 more source

The Regulation and Expression of the Creatine Transporter: A Brief Review of Creatine Supplementation in Humans and Animals

Journal of the International Society of Sports Nutrition, 2006
Creatine monohydrate has become one of the most popular ergogenic sport supplements used today. It is a nonessential dietary compound that is both endogenously synthesized and naturally ingested through diet. Creatine ingested through supplementation has
Greenwood Mike, Willoughby Darryn, Schoch Ryan D   +2 more
doaj   +1 more source

Distribution of the creatine transporter throughout the human brain reveals a spectrum of creatine transporter immunoreactivity [PDF]

Journal of Comparative Neurology, 2014
ABSTRACTCreatine is a molecule that supports energy metabolism in cells. It is carried across the plasma membrane by the creatine transporter. There has been recent interest in creatine for its neuroprotective effects in neurodegenerative diseases and its potential as a therapeutic agent.
Matthew T J, Lowe, Richard L M, Faull, David L, Christie, Henry J, Waldvogel   +3 more
openaire   +2 more sources

From broiler breeder hen feed to the egg and embryo: The molecular effects of guanidinoacetate supplementation on creatine transport and synthesis

Poultry Science, 2020
Supplementation of broiler breeder hens with beneficial additives bears great potential for affecting nutrient deposition into the fertile egg. Guanidinoacetate (GAA) is the endogenous precursor of creatine that is used as a feed additive for improving ...
Naama Reicher, Tomer Epstein, Dor Gravitz, Avigdor Cahaner, Meike Rademacher, Ulrike Braun, Zehava Uni   +6 more
doaj   +1 more source

Negative Regulation of the Creatine Transporter SLC6A8 by SPAK and OSR1

Kidney & Blood Pressure Research, 2014
Background/Aims: Transport regulation involves several kinases including SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), which are under control of WNK (with-no-K[Lys]) kinases.
Myriam Fezai, Bernat Elvira, Jose Borras, Mossadok Ben-Attia, Zohreh Hoseinzadeh, Florian Lang   +5 more
doaj   +1 more source

Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF

Fluids and Barriers of the CNS, 2022
Background Guanidinoacetate (GAA) induces epileptogenesis and neurotoxicity in the brain. As epileptic animal models have been reported to show elevated cerebral GAA levels, the processing mechanism of GAA in the brain is important for maintaining brain ...
Ryuta Jomura, Shin-ichi Akanuma, Yoshiyuki Kubo, Masanori Tachikawa, Ken-ichi Hosoya   +4 more
doaj   +1 more source