UDP‐glucose dehydrogenase variants cause dystroglycanopathy
Annals of Clinical and Translational Neurology, EarlyView.Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs +8 more
wiley +1 more source
Importance of Urinary NGAL Relative to Serum Creatinine Level for Predicting Acute Neonatal Kidney Injury [PDF]
Iranian Journal of Neonatology, 2020 Background: The diagnosis of acute kidney injury (AKI) is focused on the measurement of glomerular filtration rate based on serum creatinine; nevertheless, due to the effects of the underlying confounding parameters, this procedure tends to have some ...
Nastaran Khosravi +6 more
doaj +1 more source
Determination of creatinine and creatine by capillary electrophoresis : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Chemistry at Massey University [PDF]
, 1998 The assessment of creatinine and creatine in biological fluids is important in the evaluation of renal and muscular functions. For routine creatinine determinations in the clinical laboratory, the most frequently used method is the spectrophotometric one
Guo, Hong
core
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Environmental Chemicals in Urine and Blood: Improving Methods for Creatinine and Lipid Adjustment
Environmental Health Perspectives, 2015 Background Investigators measuring exposure biomarkers in urine typically adjust for creatinine to account for dilution-dependent sample variation in urine concentrations.
K. O’Brien +3 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Nanobubbles functionalized with indocyanine green and ischemic myocardium‐targeting peptide effectively target cardiomyocytes and enable the multimodal (fluorescence, ultrasonic, and photoacoustic) imaging of ischemic myocardium in mice with coronary microvascular dysfunction (CMD).
Bo Yu +8 more
wiley +1 more source
Immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis
Journal of Education, Health and Sport, 2021 Background. We have previously shown that nitrogenous metabolites have immunomodulatory effects in healthy rats and humans as well as in patients with encephalopatia.
Igor Kuchma +5 more
doaj +1 more source
Scale-invariant biomarker discovery in urine and plasma metabolite fingerprints [PDF]
, 2017 Motivation: Metabolomics data is typically scaled to a common reference like a constant volume of body fluid, a constant creatinine level, or a constant area under the spectrum. Such normalization of the data, however, may affect the selection of biomarkers and the biological interpretation of results in unforeseen ways.
arxiv +1 more source
The Contribution of Blood Serum Biomarkers to the Prediction of Cognitive Decline by fMRI and Apolipoprotein-E in Healthy Older Adults [PDF]
, 2012 Biomarkers are a promising approach to the prediction and early intervention of Alzheimer\u27s disease. We demonstrated that cortical functional MRI (fMRI) activation during a semantic memory task and apolipoprotein-E ?4 allele inheritance (APOE?4 ...
Durgerian, Sally +6 more
core +2 more sources
Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction
Advanced Materials, EarlyView.The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang +12 more
wiley +1 more source