Results 71 to 80 of about 100,185 (258)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Motim: laughter’s ‘relational thinking’ as contagion in a process dramaturgy

Revista Brasileira de Estudos da Presença, 2017
This paper discusses the creative process of the street performance Motim (Mutiny) (2015) from the perspective of laughter as a bio-potent performative action.
Roberta Ramos Marques, Liana Gesteira Costa   +1 more
doaj  

Creative Self-Beliefs of Civilian and Military School Students

Psico-USF
Creative Self-Efficacy (CSE) and Creative Personal Identity (CPI) are creative self-beliefs which act as creative achievement predictors in different contexts, including school.
Gabriel de Oliveira Jorge, Denise de Souza Fleith   +1 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Creative Motor Actions As Emerging from Movement Variability

Frontiers in Psychology, 2017
In cognitive science, creative ideas are defined as original and feasible solutions in response to problems. A common proposal is that creative ideas are generated across dedicated cognitive pathways.
Dominic Orth, Dominic Orth, John van der Kamp, John van der Kamp, Daniel Memmert, Geert J. P. Savelsbergh, Geert J. P. Savelsbergh   +6 more
doaj   +1 more source

Why the Standard Definition of Creativity Fails to Capture the Creative Act

Theory & Psychology, 2023
The standard definition of creativity holds that a creative idea is one that is novel and useful. Studies that follow from the standard definition and its derivatives tend to adopt an external frame of reference when estimating the level of creativity of an idea.
openaire   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

FREEDOM OF CREATIVITY AND CREATIVE IMAGINATION. MAN AND HIS TIME

Высшее образование в России, 2018
Man as a creative personality desires for freedom as well as cognition and creative work as his essence. It should be noted, however, that what we know about ourselves and how we see ourselves are far from being the same thing.
A. E. Razumov
doaj  

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source