Results 41 to 50 of about 281,244 (243)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

БУДДИЙСКАЯ ИНФОРМАТИКА НА ТАЙВАНЕ: КАК ЗВУЧИТ «БАРАБАН ДХАРМЫ»?¹

Библиосфера, 2011
A review of the collection of Buddhist information resources developed by the Dharma Drum Buddhist College in Taiwan is carried out. Thoroughly observed are themes and content of these resources, methods of implementation and copy right policy are ...

doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Creative Commons

, 2005
Creative Commons stellen ein Lizenzmodell dar, das dem Autor ermöglicht, seine Werke unter Wahrung seines Urheberrechts zur Nachnutzung und eventuellen Bearbeitung freizugeben. Creative Commons stellen dazu leicht verständliche Beschreibungen der Lizenzen und eine maschinenlesbare Darstellung zur Verfügung.
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Where Is Berlin? Cultural Commons and Urban Policy Among Real and Virtual Walls

European Journal of Creative Practices in Cities and Landscapes, 2020
“Poor but Sexy” is Berlin, in a well-known institutional slogan. The city has experienced a unique evolution since the end of World War II and the Cold War years, attracting creative talents who crafted a metropolitan and cosmopolitan network of fertile ...
Chiara Carolina Donelli, Michele Trimarchi   +1 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Synthesis and Characterization of Sulfamic Acid-Functionalized Nanoparticles and Study of Its Catalytic Activity for the Oxidation of Sulfides to Sulfoxides

Croatica Chemica Acta, 2016
The synthesis, characterization and applications of sulfamic acid-functionalized magnetic nanoparticles as a magnetically separable nanocatalyst are described.
Arash Ghorbani-Choghamarani, Gouhar Azadi   +1 more
doaj   +1 more source