Results 141 to 150 of about 643,233 (285)

Developing the rural creative economy 'from below': exploring practices of market-building amongst creative entrepreneurs in rural and remote Scotland [PDF]

open access: yes, 2016
The article draws on material gathered as part of three research projects, the first, ‘Supporting Creative Business’ was funded by the UK Arts and Humanities Research Council, the second, ‘Towards a model of support for the rural creative industries’ was
Munro, Ealasaid
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

The geography of creative industries in Europe: Comparing France, Great Britain, Italy and Spain [PDF]

open access: yes, 2010
The creative economy is a holistic and multidisciplinary concept that deals with the interaction between economics, culture and technology, and centred on the production of creative contents in goods and services.
Capone, Francesco   +4 more
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

CREATIVE INDUSTRIES

open access: yes, 2012
O artigo traça um painel das discussões sobre indústrias criativas, trazendo as diversas visões e definições sobre o tema, suas relações com outras áreas do conhecimento e da economia, discorrendo ainda sobre seus aspectos econômicos e apresentando um panorama das políticas públicas para o setor.
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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