Results 121 to 130 of about 647,155 (304)
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Where Is the Rural Creative Class? A Systematic Literature Review About Creative Industries in Low-Density Areas. [PDF]
J Knowl Econ, 2023 Silva SR, Marques CSE, Galvão AR.
europepmc +1 more source
ECONOMIC CONTRIBUTION OF COPYRIGHT-BASED INDUSTRIES AND IMPACT ON EMPLOYMENT AND PERFORMANCE INDICATORS IN KNOWLEDGE-BASED SOCIETY DEVELOPING IN ROMANIA [PDF]
The economic dimension of copyright-based industries sector in Romania is becoming of higher interest, on the one hand, for policy-makers taking into consideration its increasing contribution to GDP, employment, foreign trade and investment and, on the ...
Gheorghe ZAMAN, Valentina VASILE
core
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
New forms of finance and funding in the cultural and creative industries. Introduction to the special issue. [PDF]
J Cult Econ (Dordr), 2022 Loots E +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
New creative careers: the problems of progression and uncertainty [PDF]
, 2011 This chapter presents findings from research which we conducted with participants who were current and former art college students, practitioners in different areas of creative arts and design, and therefore workers in a relatively newly named part of ...
Littleton, Karen, Taylor, Stephanie
core
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Innovation and diversity in the digital cultural and creative industries. [PDF]
J Cult Econ (Dordr), 2021 Snowball J, Tarentaal D, Sapsed J.
europepmc +1 more source