Results 71 to 80 of about 647,155 (304)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Potential Application of The Zero Waste Fashion Method to Optimize Fabric Usage

open access: yesJurnal Ilmu Lingkungan
The fashion industry is one of the largest economic sectors globally, having a significant impact on the environment and society. Comparison between zero waste fashion pattern techniques and conventional pattern techniques is the main focus in efforts to
Faradillah Nursari   +2 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

“Creative?”… “Entrepreneur?” – Understanding the Creative Industries Entrepreneur

open access: yesArtivate, 2016
This article explores the lived experience of being an entrepreneur in the creative industries. Entrepreneurial and creative organizations are frequently cited as necessary ingredients for thriving economies. While the individual/society nexus has been well documented by entrepreneurship scholars, the experiences of individuals within the creative ...
openaire   +2 more sources

Why do creative industries cluster? An analysis of the determinants of clustering of creative industries [PDF]

open access: yes
Creative industries tend to concentrate mainly around large- and medium-sized cities, forming creative local production systems. The text analyses the forces behind clustering of creative industries to provide the first empirical explanation of the ...
Francesco Capone   +2 more
core  

Does related variety matter for creative employment growth? [PDF]

open access: yes, 2015
Little progress has been made in the mitigation of the controversies surrounding creativity and its role for local economic development (FLORIDA, 2002; PECK, 2005).
SIMONE, ANDREA
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The strategic challenges of academic collaboration between UK and China in relationship to employability and creative curriculum [PDF]

open access: yes, 2010
The rise of the creative industries and their importance to economic growth provides the context for this paper that attempts to explore China/UK curriculum approaches to employability and entrepreneurial practices for fashion design. The paper is based
Hammond, Lynne
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Deadly Hopes in Trans Women’s Lives: Comparison of Indonesian Film “Lovely Man” and Japanese Film “Midnight Swan

open access: yesHumanities
This paper will discuss the depiction of trans women in the films Lovely Man and Midnight Swan, comparing the two main characters, Ipuy and Nagisa.
Marisa Rianti Sutanto   +2 more
doaj   +1 more source

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