Results 81 to 90 of about 2,059,009 (310)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Creative Industries Innovation Centre Case Study - foolscap.pdf

open access: yes, 2015
In 2011, the Creative Industries Innovation Centre (Creative Industries Innovation Centre) worked with its industry partners to select 50 high potential creative enterprises from around the nation to participate in a series of business model workshops ...
Creative Industries Innovation Centre
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Creative work beyond the Creative Industries: an introduction [PDF]

open access: yes, 2014
Creative workers are employed in sectors outside the creative industries often in greater numbers than within the creative field. This is the first book to explore the phenomena of the embedded creative and creative services through a range of sectors, disciplines, and perspectives.
Hearn, Greg   +3 more
openaire   +4 more sources

Valuing Australia's Creative Industries - Final Report - December 2013.pdf

open access: yes, 2015
Reports on the value of Australia's Creative Industries, giving an overview of the current sector, best practice, and the Nesta method. Profiles the Australian sector, with specific information on the creative industries workforce, employment, embedded ...
Creative Industries Innovation Centre, SGS Economics
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Creative Industries Innovation Centre Case Study - One Third.pdf

open access: yes, 2015
PDF version of an article written for the Creative Industries Innovation Website creativeinnovation.net.au, part of a series of articles showcasing the experience and knowledge of companies in the creative industries in Australia.
Creative Industries Innovation Centre
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Creative Industries Innovation Centre Case Study - The Glue Society.pdf

open access: yes, 2015
PDF version of an article written for the Creative Industries Innovation Website creativeinnovation.net.au, part of a series of articles showcasing the experience and knowledge of companies in the creative industries in Australia.
Creative Industries Innovation Centre
core  

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