Results 51 to 60 of about 49,409 (237)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

CREATIVE PERFORMANCE: DAMPAK WORK ENVIRONMENT DAN CREATIVE SELF-EFFICACY (Studi Kasus di PT. Putra Mojo Maju Jaya Abadi

Jurnal Riset Manajemen Sains Indonesia, 2020
Penelitian ini bertujuan untuk menganalisis dampak work environment (WE) terhadap creative performance (CP) melalui mediasi creative self-efficacy (CSE) karyawan PT. Putra Mojo Maju Jaya Abadi.
Sesilya Kempa, Stephen Eric
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The importance of creativity and self-efficacy in enterprise education

The Irish Journal of Management
Abstract Enterprise education is lauded as a mechanism for transferring entrepreneurial skills, mindsets, and tendencies to students. We examine the changing levels of entrepreneurial tendencies of a cohort of students of enterprise education, focusing on entrepreneurial selfefficacy and entrepreneurial intentions.
Lyons, Roisin, Mac an Bhaird, Ciaran, McConalogue, Eoghan   +2 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Harnessing Creativity for Enterprise: Self-Efficacy as Catalyst.

AFRICAN JOURNAL OF APPLIED RESEARCH
Purpose:  The study examined the interplay between self-efficacy, creative potential, creative anxiety, and students' entrepreneurial intent in the creative sector. Design/methodology/approach – the paper, anchored on the Componential Model of Creativity, adopted a quantitative approach involving 378 students selected based on the UK’s Department of ...
Senayah, W. K., Tei-Narh, N., Biney-Aidoo, V.   +2 more
openaire   +2 more sources

Enhance creativity and creative self-efficacy. An action research with Italian children

New Trends and Issues Proceedings on Humanities and Social Sciences, 2020
Creativity is a human resource that allows individuals to solve problems in a new way and propose changes. It is related to creative self-efficacy that regards individual belief to be creative. The present study explored the effects of a training to enhance creativity and creative self-efficacy in 34 Italian children, aged between 8 and 10 years and ...
Falanga R., De Caroli M. E., Sagone E., Maugeri M. R.   +3 more
openaire   +4 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Effectiveness of a mindfulness-based training program to improve creative self-efficacy among a sample of secondary school students

Creativity Studies
To motivating creativity among students, creative self-efficacy is one of the most important indicators, as it refers to individuals’ beliefs about their creative abilities, their motivation towards creativity, and possession of the necessary knowledge ...
Ahmad M. Mahasneh, Ahmad M. Gazo
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source