Results 61 to 70 of about 6,800,841 (273)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Examining the Effects of Individual's Polychronicity and Supervisor's Management Style on Creative Self-Efficacy

, 2008
This research focuses on the area of individuals' creative self-efficacy studies in the workplace. Creative self-efficacy is the self belief of whether one has the capacity to perform the job creatively.
Ma, Xiaofang (11682595)
core   +1 more source

Harnessing Creativity for Enterprise: Self-Efficacy as Catalyst.

AFRICAN JOURNAL OF APPLIED RESEARCH
Purpose:  The study examined the interplay between self-efficacy, creative potential, creative anxiety, and students' entrepreneurial intent in the creative sector. Design/methodology/approach – the paper, anchored on the Componential Model of Creativity, adopted a quantitative approach involving 378 students selected based on the UK’s Department of ...
Senayah, W. K., Tei-Narh, N., Biney-Aidoo, V.   +2 more
openaire   +2 more sources

Investigating the Relationship Between Students’ Creative Self-efficacy and Their Creative Outcomes [PDF]

2015 ASEE Annual Conference and Exposition Proceedings, 2015
Investigating the Relationship Between Students’ Creative Self-Efficacy and their Creative Outcomes (RTP-Strand 5)This paper examines the relationship between creative self-efficacy and creativeoutcomes for students participating in an engineering summer camp at a major researchinstitution. The case has been made for an increased emphasis on creativity
Cameron Denson, Jennifer Buelin-Biesecker   +1 more
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CREATIVE PERFORMANCE: DAMPAK WORK ENVIRONMENT DAN CREATIVE SELF-EFFICACY (Studi Kasus di PT. Putra Mojo Maju Jaya Abadi

Jurnal Riset Manajemen Sains Indonesia, 2020
Penelitian ini bertujuan untuk menganalisis dampak work environment (WE) terhadap creative performance (CP) melalui mediasi creative self-efficacy (CSE) karyawan PT. Putra Mojo Maju Jaya Abadi.
Sesilya Kempa, Stephen Eric
doaj   +1 more source

The importance of creativity and self-efficacy in enterprise education

The Irish Journal of Management
Abstract Enterprise education is lauded as a mechanism for transferring entrepreneurial skills, mindsets, and tendencies to students. We examine the changing levels of entrepreneurial tendencies of a cohort of students of enterprise education, focusing on entrepreneurial selfefficacy and entrepreneurial intentions.
Lyons, Roisin, Mac an Bhaird, Ciaran, McConalogue, Eoghan   +2 more
openaire   +2 more sources