Results 91 to 100 of about 1,395,541 (300)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Developing the Management Competencies for Getting a Competitive Position in the Organic Food Market [PDF]

Although almost any conference tackles the issue of organic foods, we consider that this article does not fit into normal patterns of research. Our paper proposes a complex analysis in the field of organic food products.
Marian NASTASE, Mirela STOIAN, Raluca Andreea ION   +2 more
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The Analysis of Creative and Innovative Thinking Skills of the 21st Century Students in Solving the Problems of “Locating Dominating Set” in Research Based Learning [PDF]

, 2018
In the 21st century, creative and innovative thinking skill is greatly required. According to the P21 platform (Partnership for 21st century learning), someone will survive in the 21stcentury if they have the skills of creative and innovative skills ...
Dafik, D. (Dafik), Yudha, F. (Firma), Yuliati, N. (Nanik)   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Functional System of Creative Thinking [PDF]

, 2016
In the article on the basis of electroencephalographic and psychological indicators the concept the mechanism of creative thinking was formulated. Creative thinking as a process involves operating images and searching similar tasks in memory (mental ...
Abramchuk, Olha M., Dmytrotsa, Olena R., Kachynska, Tetiana V., Kotsan, Ihor Ya., Kozachuk, Nataliia O., Poruchynska, Tetiana F., Poruchynskyi, Andrii I., Shvarts, Liudmyla O., Zhuravlov, Oleksandr A., Абрамчук, Ольга Миколаївна, Дмитроца, Олена Романівна, Журавльов, Олександр Анатолійович, Качинська, Тетяна Володимирівна, Козачук, Наталія Олександрівна, Коцан, Ігор Ярославович, Поручинська, Тетяна Федорівна, Поручинський, Андрій Іванович, Шварц, Людмила Олексіївна   +17 more
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TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Kemampuan Berpikir Kreatif Siswa Melalui Creative Problem Solving [PDF]

, 2016
Creative thinking ability is the one of important things in mathematics lesson. In developing such creative thinking ability, teachers must be good at giving ideas and issues which are relatively different from before, so that we can find something new ...
Afriansyah, E. A. (Ekasatya), Tarlina, W. H. (Windi)   +1 more
core  

The Use of Interactive Multimedia (Macromedia Flash) to Increase Creative Thinking Ability of Students in Basic Physics Subject [PDF]

, 2017
Students were intellectuals who should have the ability to think critically, one of which is the creative thinking skills. However, the students' limited ability in basic physics as well as the limitations of using a variety of multimedia resulted in ...
Marnita, M. (M)
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Mathematical Creative Thinking and Student Self-Confidence in the Challenge-Based Learning Approach

Journal of Research and Advances in Mathematics Education, 2018
The new curriculum (K13) requires a teacher to develop students’ ability in order to learn and fully understand Mathematics. The important abilities needed for a student in understanding Mathematics are the creative thinking and self-confidence.
Hayatun Nufus, Muhammad Duskri, Bahrun Bahrun   +2 more
doaj   +1 more source