Results 91 to 100 of about 1,403,002 (296)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Gesture Facilitates Children’s Creative Thinking [PDF]

, 2016
Gestures help people think and can help offer new ideas to problem solvers. We conducted two experiments exploring the self-oriented function of gesture in a novel domain; creative thinking. In Experiment 1 we explored the relationship between children’s
Carine Lewis, Dunn L. M., Elizabeth Kirk, Guilford J. P.   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Kemampuan Berpikir Kreatif Siswa Melalui Creative Problem Solving [PDF]

, 2016
Creative thinking ability is the one of important things in mathematics lesson. In developing such creative thinking ability, teachers must be good at giving ideas and issues which are relatively different from before, so that we can find something new ...
Afriansyah, E. A. (Ekasatya), Tarlina, W. H. (Windi)   +1 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Does design education always produce designers?

, 2011
By questioning what we mean by the term ‘designer’ this paper describes the ideas behind a new Open University course in Design Thinking. The paper shows how the creative skills of students can be consciously developed, and deliberately applied outside ...
Lloyd, Peter
core  

Profil Tingkat Berpikir Kreatif Siswa Kelas VII SMP Negeri 16 Surakarta Dalam Pemecahan Masalah Aritmatika Sosial Ditinjau Dari Motivasi Dan Gender [PDF]

, 2013
. This study aimed to describe: (1) the creative thinking level of male Junior High School students, who had high motivation in solving some problems in appropriate to Polya's Steps, (2) the creative thinking level of female Junior High School students ...
Iswahyudi, G. (Gatut), Kusmayadi, T. A. (Tri), Sunarya, L. (Linda)   +2 more
core  

Approaches to teaching: Current opinions and related research [PDF]

, 2005
Three approaches to teaching and learning are introduced. Each approach has its relative merits and disadvantages. Ideally, each approach should not be used in isolation. The use of facilitatory approaches to teaching and learning should be encouraged to
Argyris, Ashby, Banning, Brookfield, Brookfield, Brownhill, Clancy, Cooke, Cortazzi, Davies, Davies, Engle, Entwistle, Eraut, Fowler, Freeth, Gallacher, Gilmartin, Glover, Gow, Gregory, Griffin, Haith-Cooper, Haith-Cooper, Hendry, Hufton, Jarvis, Jarvis, Knowles, Knowles, Latter, Laurillard, Laurilliard, Lee, Liimatainen, Maggi Banning, Marton, McKee, Newstead, O’Neill, Preece, Rogers, Seymour, Tight, Trigwell, Walkin   +45 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source