Results 121 to 130 of about 1,395,541 (300)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Managing systemic risk using systems thinking in practice [PDF]

, 2013
Managing uncertainties associated with, say, water security, toxic wastes, or biotechnology, invites growing relevance from the field of complexity sciences that everything is connected.
Reynolds, Martin
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Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Efektivitas Model Problem Based Instruction dan Guided Discovery Learning Terhadap Kemampuan Berpikir Kreatif Peserta Didik Kelas X SMA Negeri 4 Magelang Tahun Ajaran 2014/2015 (Kompetensi Dasar Hidrosfer dan Dampaknya Terhadap Kehidupan di Muka Bumi) [PDF]

, 2016
Bonita Alfi Nurandini (K5411011) THE EFFECTIVITY OF PROBLEM BASED INSTRUCTION MODEL AND GUIDED DISCOVERY LEARNING MODEL TOWARD CREATIVE THINKING ABILITY OF TENTH GRADE STUDENTS IN SMA NEGERI 4 MAGELANG ACADEMIC YEAR 2014/2015 (Basic Competence of ...
N, BONITA ALFI
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KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Pengaruh Model Pembelajaran Inkuiri Laboratorium Terhadap Keterampilan Berpikir Kreatif Dan Keterampilan Proses Sains Siswa Ditinjau Dari Kemandirian Belajar Siswa [PDF]

, 2012
The aims of this study was to (1) analyze the differences in creative thinking skills and science process skills between students who studied through inquiry laboratory learning model and conventional learning model, (2) analyze the interaction effect ...
Sanjaya, I. P. (I)
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Pengembangan Perangkat Pembelajaran Model Guided Inquiry untuk Meningkatkan Creative Thinking Siswa [PDF]

, 2018
Penelitian ini merupakan penelitian pengembangan (R&D) menggunakan model pengembangan yang diadaptasi dariBorg dan Gall. Penelitian ini bertujuan untuk (1) menghasilkan perangkat pembelajaran Biologi dengan model Guided Inquiry yang layak untuk ...
Fikri, A. A. (Achmad), Ismah, V. (Viki), Paidi, P. (Paidi)   +2 more
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