Results 121 to 130 of about 1,391,241 (279)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Managing systemic risk using systems thinking in practice [PDF]
, 2013 Managing uncertainties associated with, say, water security, toxic wastes, or biotechnology, invites growing relevance from the field of complexity sciences that everything is connected.
Reynolds, Martin
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Creative Thinking in Higher Education [PDF]
, 2018 Comprend des références bibliographiquesVanier Academic Voices, Vol.1, Issue 1, January ...
Cooperberg, Elana, Hoida, David
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Dynamic cycles between brain states during creative storytelling
NeuroImageMany theories suggest that creative thinking involves a dynamic transition between different mental states, yet empirical evidence supporting this notion remains scarce.
Xitong Liang +5 more
doaj +1 more source
Creative Placemaking Case Study: Brookland-Edgewood [PDF]
, 2017 This case study illustrates how Creative Placemaking, the deliberate integration of arts and culture into comprehensive community development, can serve as a critical catalyst in forming equitable living and working solutions for all the social, economic,
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Pengembangan Perangkat Pembelajaran Model Guided Inquiry untuk Meningkatkan Creative Thinking Siswa [PDF]
, 2018 Penelitian ini merupakan penelitian pengembangan (R&D) menggunakan model pengembangan yang diadaptasi dariBorg dan Gall. Penelitian ini bertujuan untuk (1) menghasilkan perangkat pembelajaran Biologi dengan model Guided Inquiry yang layak untuk ...
Fikri, A. A. (Achmad) +2 more
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