Results 231 to 240 of about 707,370 (302)

Knowledge capital: from concept to action [PDF]

, 2003
May, T, Perry, B
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The impact of chronic heroin addiction on creative cognition: an EEG study based on divergent thinking. [PDF]

Transl Psychiatry
Fu W, Wang Y, Li W, Meng Y, Dang J, Yuan K, Duan H.   +6 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Mapping data stewardship in Italy: Findings from the first national survey. [PDF]

Open Res Eur
Caldoni G, Iacovella V, Lazzeri E, Lehtsalu L, Marchegiani F, Paschetta M, Pasquale V, Pedonese G, Tarallo A.   +8 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A study on the impact of need satisfaction on perceived academic performance among arts major undergraduate students in China-focusing on the mediating effect of achievement goals orientations and the moderating effect of perceived social support. [PDF]

Front Psychol
Gao X, Chen M, Li Y.
europepmc   +1 more source

What is Media Education For? [PDF]

, 2012
Berger, Richard, McDougall, J.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effectiveness of telepsychiatry in college students: A cross sectional evaluation. [PDF]

Bioinformation
M R M, Samala M, Tiwari R, Tiwari HD, M C P, Ali T, Syed AK.   +6 more
europepmc   +1 more source