Results 91 to 100 of about 2,389,317 (254)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Stylistics in the creative writing curriculum: A problem-posing approach
, 2017 The synergies between creative writing instruction and stylistic analysis have been noted for more than a decade in the Stylistics literature – see for example Michael Burke (2010: 7; 2013), Jeremy Scott (2013a; 2013b: 99), et al – but there remain very ...
Bolland, Craig
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
國小師資生國語發音錯誤之調查與分析 Investigation and Analysis of Mandarin Pronunciation Errors among Elementary Pre-service Teachers [PDF]
Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan教學中，教師的口齒清晰、表達流暢是相當重要的。臺灣的國小師培課程當中與國語發音最有關的應是「國音及說話」這一門課，此課程也是國語文教材法的先修課程，其重要性不言而喻。研究者連續多年在本校師培中心開設此課程，在教學過程中發現以下問題，首先是國小師資生國語發音與標準尚有段距離，其次是觀察到教材中的發音重點與師資生的發音錯誤或有出入，且難以具體評量國小師資生國語發音現況。為解決以上問題，本研究目的為調查國小師資生國語發音偏誤類型與比例，以此為基礎，提出「國音及說話」課程在國語發音上的教學建議 ...
張金蘭 Ching-Lan Chang
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Crossings, 2015 This article addresses representations of working-class life in Britain during the 1980s; specifically, experiences of recession, unemployment, and difficulty in the workplace.
Joseph Brooker
doaj +1 more source
Musico-literary miscegenations : word and sound relationships in creative writing pedagogy
, 2017 Since 2012 I have been teaching an evolving postgraduate unit about the contemporary literature-music relationship. The unit is part of a Master of Arts (MA) in Literature and Creative Writing based in the Writing and Society Research Centre at Western ...
Smith, Hazel (R11761)
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