Results 71 to 80 of about 150,867 (259)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
國小師資生國語發音錯誤之調查與分析 Investigation and Analysis of Mandarin Pronunciation Errors among Elementary Pre-service Teachers [PDF]
Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan教學中，教師的口齒清晰、表達流暢是相當重要的。臺灣的國小師培課程當中與國語發音最有關的應是「國音及說話」這一門課，此課程也是國語文教材法的先修課程，其重要性不言而喻。研究者連續多年在本校師培中心開設此課程，在教學過程中發現以下問題，首先是國小師資生國語發音與標準尚有段距離，其次是觀察到教材中的發音重點與師資生的發音錯誤或有出入，且難以具體評量國小師資生國語發音現況。為解決以上問題，本研究目的為調查國小師資生國語發音偏誤類型與比例，以此為基礎，提出「國音及說話」課程在國語發音上的教學建議 ...
張金蘭 Ching-Lan Chang
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Crossings, 2015 This article addresses representations of working-class life in Britain during the 1980s; specifically, experiences of recession, unemployment, and difficulty in the workplace.
Joseph Brooker
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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Painting a Bibliography: Excerpts from SPEECH
Humanities, 2019 The following excerpts—rearranged especially for this condensed reading space—are from a project entitled SPEECH (Nightboat Books 2019): a book of poetry, prose, and images from an archive of paintings that were made by the author during the ...
Jill Magi
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source