Results 61 to 70 of about 136,439 (251)
Crossings, 2020 This article addresses representations of working-class life in Britain during the 1980s; specifically, experiences of recession, unemployment, and difficulty in the workplace.
Joseph Brooker
doaj +1 more source
Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence
Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
國小師資生國語發音錯誤之調查與分析 Investigation and Analysis of Mandarin Pronunciation Errors among Elementary Pre-service Teachers [PDF]
Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan教學中，教師的口齒清晰、表達流暢是相當重要的。臺灣的國小師培課程當中與國語發音最有關的應是「國音及說話」這一門課，此課程也是國語文教材法的先修課程，其重要性不言而喻。研究者連續多年在本校師培中心開設此課程，在教學過程中發現以下問題，首先是國小師資生國語發音與標準尚有段距離，其次是觀察到教材中的發音重點與師資生的發音錯誤或有出入，且難以具體評量國小師資生國語發音現況。為解決以上問題，本研究目的為調查國小師資生國語發音偏誤類型與比例，以此為基礎，提出「國音及說話」課程在國語發音上的教學建議 ...
張金蘭 Ching-Lan Chang
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Crossings, 2015 This article addresses representations of working-class life in Britain during the 1980s; specifically, experiences of recession, unemployment, and difficulty in the workplace.
Joseph Brooker
doaj +1 more source